ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TOM1-like protein 1

Intramolecular
Cysteine 79 and cysteine 83
Cysteine 39 and cysteine 83
Cysteine 39 and cysteine 79
A redox-regulated disulphide may form within TOM1-like protein 1 between cysteines 79 and 83.

Details

Redox score ?
86
PDB code
3rru
Structure name
x-ray crystal structure of the vhs domain of human tom1-like protein, northeast structural genomics consortium target hr3050e
Structure deposition date
2011-04-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
4
% buried
70
Peptide accession
Q8N749
Residue number A
79
Residue number B
83
Peptide name
TOM1-like protein 1

Ligandability

Cysteine 79 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TOM1-like protein 1 between cysteines 39 and 83.

Details

Redox score ?
83
PDB code
3rru
Structure name
x-ray crystal structure of the vhs domain of human tom1-like protein, northeast structural genomics consortium target hr3050e
Structure deposition date
2011-04-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
4
% buried
50
Peptide accession
Q8N749
Residue number A
39
Residue number B
83
Peptide name
TOM1-like protein 1

Ligandability

Cysteine 39 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TOM1-like protein 1 between cysteines 39 and 79.

Details

Redox score ?
72
PDB code
3rru
Structure name
x-ray crystal structure of the vhs domain of human tom1-like protein, northeast structural genomics consortium target hr3050e
Structure deposition date
2011-04-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
72
Peptide accession
Q8N749
Residue number A
39
Residue number B
79
Peptide name
TOM1-like protein 1

Ligandability

Cysteine 39 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of TOM1-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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