ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Arf-GAP with dual PH domain-containing protein 1

Intramolecular
Cysteine 24 and cysteine 44
Cysteine 21 and cysteine 44
Cysteine 41 and cysteine 44
Cysteine 21 and cysteine 41
Cysteine 21 and cysteine 24
Cysteine 24 and cysteine 41
A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 24 and 44.

Details

Redox score ?
76
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
24
Residue number B
44
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 24 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 44 of Arf-GAP with dual PH domain-containing protein 1

A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 21 and 44.

Details

Redox score ?
76
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
21
Residue number B
44
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 21 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 44 of Arf-GAP with dual PH domain-containing protein 1

A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 41 and 44.

Details

Redox score ?
75
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
41
Residue number B
44
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 41 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 44 of Arf-GAP with dual PH domain-containing protein 1

A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 21 and 41.

Details

Redox score ?
74
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
21
Residue number B
41
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 21 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 41 of Arf-GAP with dual PH domain-containing protein 1

A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 21 and 24.

Details

Redox score ?
74
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
21
Residue number B
24
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 21 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 24 of Arf-GAP with dual PH domain-containing protein 1

A redox-regulated disulphide may form within Arf-GAP with dual PH domain-containing protein 1 between cysteines 24 and 41.

Details

Redox score ?
73
PDB code
3mdb
Structure name
crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4
Structure deposition date
2010-03-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75689
Residue number A
24
Residue number B
41
Peptide name
Arf-GAP with dual PH domain-containing protein 1

Ligandability

Cysteine 24 of Arf-GAP with dual PH domain-containing protein 1

Cysteine 41 of Arf-GAP with dual PH domain-containing protein 1

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