ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nuclear pore complex protein Nup155

Intramolecular
Cysteine 704 and cysteine 799
Cysteine 917 and cysteine 974
Cysteine 102 and cysteine 104
Cysteine 548 and cysteine 551
Cysteine 356 and cysteine 373
Cysteine 551 and cysteine 556
A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 704 and 799. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7eye
Structure name
cryo-em (spa) structure of nup155 n-terminus (19-863) at 5
Structure deposition date
2021-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
O75694
Residue number A
704
Residue number B
799
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 704 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 799 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 917 and 974. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7eyq
Structure name
cryo-em (spa) structure of human nup155 longer n-terminus (19-1069) at 5
Structure deposition date
2021-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
40
Peptide accession
O75694
Residue number A
917
Residue number B
974
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 917 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 974 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 102 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7eyq
Structure name
cryo-em (spa) structure of human nup155 longer n-terminus (19-1069) at 5
Structure deposition date
2021-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
10
Peptide accession
O75694
Residue number A
102
Residue number B
104
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 102 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 548 and 551. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7eye
Structure name
cryo-em (spa) structure of nup155 n-terminus (19-863) at 5
Structure deposition date
2021-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
88
Peptide accession
O75694
Residue number A
548
Residue number B
551
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 548 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 551 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 356 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7eye
Structure name
cryo-em (spa) structure of nup155 n-terminus (19-863) at 5
Structure deposition date
2021-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
66
Peptide accession
O75694
Residue number A
356
Residue number B
373
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 356 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear pore complex protein Nup155 between cysteines 551 and 556 (537 and 542 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7r1y
Structure name
cryoem structure of human nup155 (residues 19-981)
Structure deposition date
2022-02-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
98
Peptide accession
O75694
Residue number A
551
Residue number B
556
Peptide name
Nuclear pore complex protein Nup155

Ligandability

Cysteine 551 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 556 of Nuclear pore complex protein Nup155

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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