Ribonuclease P protein subunit p20

Intermolecular

Cysteine 146 of Ribonuclease P/MRP protein subunit POP5 and cysteine 66 L

Intramolecular

A redox-regulated disulphide may form between cysteine 146 of Ribonuclease P/MRP protein subunit POP5 and cysteine 66 of Ribonuclease P protein subunit p20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6ahr

Structure name

cryo-em structure of human ribonuclease p

Structure deposition date

2018-08-20

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Ribonuclease P/MRP protein subunit POP5

Peptide B name

Ribonuclease P protein subunit p20

Peptide A accession

Q969H6

Peptide B accession

O75817

Peptide A residue number

146

Peptide B residue number

Ligandability

Cysteine 146 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Ribonuclease P protein subunit p20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease P protein subunit p20 between cysteines 52 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?