ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Signal transducing adapter molecule 2

Intramolecular
Cysteine 33 and cysteine 76
Cysteine 33 and cysteine 72
Cysteine 72 and cysteine 76
Cysteine 46 and cysteine 72
Cysteine 46 and cysteine 76
Cysteine 33 and cysteine 46
A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 33 and 76 (40 and 83 respectively in this structure).

Details

Redox score ?
73
PDB code
1x5b
Structure name
the solution structure of the vhs domain of human signal transducing adaptor molecule 2
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
42
Peptide accession
O75886
Residue number A
33
Residue number B
76
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 33 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 33 and 72 (40 and 79 respectively in this structure).

Details

Redox score ?
72
PDB code
1x5b
Structure name
the solution structure of the vhs domain of human signal transducing adaptor molecule 2
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
56
Peptide accession
O75886
Residue number A
33
Residue number B
72
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 33 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 72 and 76 (79 and 83 respectively in this structure).

Details

Redox score ?
67
PDB code
1x5b
Structure name
the solution structure of the vhs domain of human signal transducing adaptor molecule 2
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
64
Peptide accession
O75886
Residue number A
72
Residue number B
76
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 72 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 46 and 72 (53 and 79 respectively in this structure).

Details

Redox score ?
64
PDB code
2l0t
Structure name
solution structure of the complex of ubiquitin and the vhs domain of stam2
Structure deposition date
2010-07-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
91
Peptide accession
O75886
Residue number A
46
Residue number B
72
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 46 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 46 and 76 (53 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2l0t
Structure name
solution structure of the complex of ubiquitin and the vhs domain of stam2
Structure deposition date
2010-07-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
76
Peptide accession
O75886
Residue number A
46
Residue number B
76
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 46 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducing adapter molecule 2 between cysteines 33 and 46 (40 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2l0t
Structure name
solution structure of the complex of ubiquitin and the vhs domain of stam2
Structure deposition date
2010-07-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
86
Peptide accession
O75886
Residue number A
33
Residue number B
46
Peptide name
Signal transducing adapter molecule 2

Ligandability

Cysteine 33 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Signal transducing adapter molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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