Matrix metalloproteinase-23
Intramolecular
Cysteine 256 and cysteine 290
Cysteine 263 and cysteine 283
Cysteine 272 and cysteine 287
Cysteine 283 and cysteine 287
Cysteine 263 and cysteine 287
Cysteine 263 and cysteine 272
Cysteine 272 and cysteine 283
Cysteine 287 and cysteine 290
Cysteine 256 and cysteine 283
Cysteine 256 and cysteine 263
More...Cysteine 283 and cysteine 290
Cysteine 256 and cysteine 287
2k72 A 3 A 37
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 256 and 290 (3 and 37 respectively in this structure).
Details
Redox score ?
92
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
256
Residue number B
290
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 256 of Matrix metalloproteinase-23
Cysteine 290 of Matrix metalloproteinase-23
2k72 A 10 A 30
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 263 and 283 (10 and 30 respectively in this structure).
Details
Redox score ?
86
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
263
Residue number B
283
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 263 of Matrix metalloproteinase-23
Cysteine 283 of Matrix metalloproteinase-23
2k72 A 19 A 34
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 272 and 287 (19 and 34 respectively in this structure).
Details
Redox score ?
85
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
272
Residue number B
287
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 272 of Matrix metalloproteinase-23
Cysteine 287 of Matrix metalloproteinase-23
2k72 A 30 A 34
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 283 and 287 (30 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
283
Residue number B
287
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 283 of Matrix metalloproteinase-23
Cysteine 287 of Matrix metalloproteinase-23
2k72 A 10 A 34
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 263 and 287 (10 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
263
Residue number B
287
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 263 of Matrix metalloproteinase-23
Cysteine 287 of Matrix metalloproteinase-23
2k72 A 10 A 19
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 263 and 272 (10 and 19 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
263
Residue number B
272
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 263 of Matrix metalloproteinase-23
Cysteine 272 of Matrix metalloproteinase-23
2k72 A 19 A 30
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 272 and 283 (19 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
272
Residue number B
283
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 272 of Matrix metalloproteinase-23
Cysteine 283 of Matrix metalloproteinase-23
2k72 A 34 A 37
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 287 and 290 (34 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
287
Residue number B
290
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 287 of Matrix metalloproteinase-23
Cysteine 290 of Matrix metalloproteinase-23
2k72 A 3 A 30
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 256 and 283 (3 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
256
Residue number B
283
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 256 of Matrix metalloproteinase-23
Cysteine 283 of Matrix metalloproteinase-23
2k72 A 3 A 10
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 256 and 263 (3 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
256
Residue number B
263
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 256 of Matrix metalloproteinase-23
Cysteine 263 of Matrix metalloproteinase-23
2k72 A 30 A 37
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 283 and 290 (30 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
283
Residue number B
290
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 283 of Matrix metalloproteinase-23
Cysteine 290 of Matrix metalloproteinase-23
2k72 A 3 A 34
A redox-regulated disulphide may form within Matrix metalloproteinase-23 between cysteines 256 and 287 (3 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2k72
Structure name
solution nmr structure of toxin-like potassium channel blocking domain in mmp23
Structure deposition date
2008-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88272
Residue number A
256
Residue number B
287
Peptide name
Matrix metalloproteinase-23
Ligandability
Cysteine 256 of Matrix metalloproteinase-23
Cysteine 287 of Matrix metalloproteinase-23
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