ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sterol O-acyltransferase 2

Intramolecular
Cysteine 319 and cysteine 493
Cysteine 307 and cysteine 361
A redox-regulated disulphide may form within Sterol O-acyltransferase 2 between cysteines 319 and 493.

Details

Redox score ?
76
PDB code
7n6r
Structure name
structure of nevanimibe bound human acat2
Structure deposition date
2021-06-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
83
Peptide accession
O75908
Residue number A
319
Residue number B
493
Peptide name
Sterol O-acyltransferase 2

Ligandability

Cysteine 319 of Sterol O-acyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 493 of Sterol O-acyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sterol O-acyltransferase 2 between cysteines 307 and 361.

Details

Redox score ?
66
PDB code
7n6q
Structure name
structure of pppa bound human acat2
Structure deposition date
2021-06-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
93
Peptide accession
O75908
Residue number A
307
Residue number B
361
Peptide name
Sterol O-acyltransferase 2

Ligandability

Cysteine 307 of Sterol O-acyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Sterol O-acyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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