ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cyclin-K

Intramolecular
Cysteine 98 and cysteine 99
Cysteine 98 and cysteine 113
A redox-regulated disulphide may form within Cyclin-K between cysteines 98 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6b3e
Structure name
crystal structure of human cdk12/cyclink in complex with an inhibitor
Structure deposition date
2017-09-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
98
Minimum pKa ?
13
% buried
100
Peptide accession
O75909
Residue number A
98
Residue number B
99
Peptide name
Cyclin-K

Ligandability

Cysteine 98 of Cyclin-K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Cyclin-K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclin-K between cysteines 98 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4cxa
Structure name
crystal structure of the human cdk12-cyclin k complex bound to amppnp
Structure deposition date
2014-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
76
Peptide accession
O75909
Residue number A
98
Residue number B
113
Peptide name
Cyclin-K

Ligandability

Cysteine 98 of Cyclin-K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Cyclin-K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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