ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

SEC14-like protein 2

Intramolecular
Cysteine 89 and cysteine 254
Cysteine 301 and cysteine 355
Cysteine 96 and cysteine 135
A redox-regulated disulphide may form within SEC14-like protein 2 between cysteines 89 and 254.

Details

Redox score ?
74
PDB code
1o6u
Structure name
the crystal structure of human supernatant protein factor
Structure deposition date
2002-10-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
46
Peptide accession
O76054
Residue number A
89
Residue number B
254
Peptide name
SEC14-like protein 2

Ligandability

Cysteine 89 of SEC14-like protein 2

Cysteine 254 of SEC14-like protein 2

A redox-regulated disulphide may form within SEC14-like protein 2 between cysteines 301 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
1olm
Structure name
supernatant protein factor in complex with rrr-alpha-tocopherylquinone: a link between oxidized vitamin e and cholesterol biosynthesis
Structure deposition date
2003-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
39
Peptide accession
O76054
Residue number A
301
Residue number B
355
Peptide name
SEC14-like protein 2

Ligandability

Cysteine 301 of SEC14-like protein 2

Cysteine 355 of SEC14-like protein 2

A redox-regulated disulphide may form within SEC14-like protein 2 between cysteines 96 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4omk
Structure name
crystal structure of spf bound to squalene
Structure deposition date
2014-01-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
72
Peptide accession
O76054
Residue number A
96
Residue number B
135
Peptide name
SEC14-like protein 2

Ligandability

Cysteine 96 of SEC14-like protein 2

Cysteine 135 of SEC14-like protein 2

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