Stanniocalcin-2
Intermolecular
Cysteine 211 and cysteine 211
Cysteine 732 of Pappalysin-1 and cysteine 120
Intramolecular
Cysteine 197 and cysteine 205
Cysteine 76 and cysteine 125
Cysteine 56 and cysteine 70
Cysteine 146 and cysteine 181
Cysteine 65 and cysteine 85
Cysteine 109 and cysteine 139
8a7e P 211 A 211
A redox-regulated disulphide may form between two units of Stanniocalcin-2 at cysteines 211 and 211.
Details
Redox score ?
94
PDB code
8a7e
Structure name
papp-a dimer in complex with its inhibitor stc2
Structure deposition date
2022-06-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Stanniocalcin-2
Peptide B name
Stanniocalcin-2
Peptide A accession
O76061
Peptide B accession
O76061
Peptide A residue number
211
Peptide B residue number
211
Ligandability
7y5q B 652 C 120
A redox-regulated disulphide may form between cysteine 732 of Pappalysin-1 and cysteine 120 of Stanniocalcin-2 (652 and 120 respectively in this structure).
Details
Redox score ?
84
PDB code
7y5q
Structure name
structure of 1:1 papp-a
Structure deposition date
2022-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pappalysin-1
Peptide B name
Stanniocalcin-2
Peptide A accession
Q13219
Peptide B accession
O76061
Peptide A residue number
732
Peptide B residue number
120
Ligandability
Cysteine 732 of Pappalysin-1
Cysteine 120 of Stanniocalcin-2
8a7e P 197 P 205
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 197 and 205.
Details
Redox score ?
87
PDB code
8a7e
Structure name
papp-a dimer in complex with its inhibitor stc2
Structure deposition date
2022-06-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
197
Residue number B
205
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 197 of Stanniocalcin-2
Cysteine 205 of Stanniocalcin-2
8a7e A 76 A 125
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 76 and 125.
Details
Redox score ?
86
PDB code
8a7e
Structure name
papp-a dimer in complex with its inhibitor stc2
Structure deposition date
2022-06-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
76
Residue number B
125
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 76 of Stanniocalcin-2
Cysteine 125 of Stanniocalcin-2
8hgh G 56 G 70
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 56 and 70.
Details
Redox score ?
84
PDB code
8hgh
Structure name
structure of 2:2 papp-a
Structure deposition date
2022-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
56
Residue number B
70
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 56 of Stanniocalcin-2
Cysteine 70 of Stanniocalcin-2
8hgh C 146 C 181
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 146 and 181.
Details
Redox score ?
84
PDB code
8hgh
Structure name
structure of 2:2 papp-a
Structure deposition date
2022-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
146
Residue number B
181
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 146 of Stanniocalcin-2
Cysteine 181 of Stanniocalcin-2
8a7d P 65 P 85
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 65 and 85.
Details
Redox score ?
83
PDB code
8a7d
Structure name
partial dimer complex of papp-a and its inhibitor stc2
Structure deposition date
2022-06-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
65
Residue number B
85
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 65 of Stanniocalcin-2
Cysteine 85 of Stanniocalcin-2
8hgh G 109 G 139
A redox-regulated disulphide may form within Stanniocalcin-2 between cysteines 109 and 139.
Details
Redox score ?
83
PDB code
8hgh
Structure name
structure of 2:2 papp-a
Structure deposition date
2022-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O76061
Residue number A
109
Residue number B
139
Peptide name
Stanniocalcin-2
Ligandability
Cysteine 109 of Stanniocalcin-2
Cysteine 139 of Stanniocalcin-2
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