ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Intramolecular
Cysteine 86 and cysteine 97 L
Cysteine 19 and cysteine 322 L
Cysteine 186 and cysteine 187
Cysteine 243 and cysteine 245 L
Cysteine 308 and cysteine 322
Cysteine 19 and cysteine 34 L
Cysteine 19 and cysteine 308 L
Cysteine 34 and cysteine 308 L
Cysteine 34 and cysteine 322 L
Cysteine 212 and cysteine 271 L
A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 86 and 97.

Details

Redox score ?
71
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
54
Peptide accession
O76071
Residue number A
86
Residue number B
97
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 86 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 97 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 19 and 322.

Details

Redox score ?
65
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
94
Minimum pKa ?
9
% buried
100
Peptide accession
O76071
Residue number A
19
Residue number B
322
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 19 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 322 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 186 and 187.

Details

Redox score ?
62
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
54
Peptide accession
O76071
Residue number A
186
Residue number B
187
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 186 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 187 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 243 and 245. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
58
Peptide accession
O76071
Residue number A
243
Residue number B
245
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 243 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 245 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 308 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
104
Minimum pKa ?
11
% buried
100
Peptide accession
O76071
Residue number A
308
Residue number B
322
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 308 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 322 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 19 and 34. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
9
% buried
100
Peptide accession
O76071
Residue number A
19
Residue number B
34
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 19 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 34 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 19 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
9
% buried
100
Peptide accession
O76071
Residue number A
19
Residue number B
308
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 19 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 308 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 34 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
103
Minimum pKa ?
11
% buried
100
Peptide accession
O76071
Residue number A
34
Residue number B
308
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 34 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 308 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 34 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
101
Minimum pKa ?
14
% buried
100
Peptide accession
O76071
Residue number A
34
Residue number B
322
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 34 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 322 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

A redox-regulated disulphide may form within Probable cytosolic iron-sulfur protein assembly protein CIAO1 between cysteines 212 and 271. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3fm0
Structure name
crystal structure of wd40 protein ciao1
Structure deposition date
2008-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
11
% buried
83
Peptide accession
O76071
Residue number A
212
Residue number B
271
Peptide name
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Ligandability

Cysteine 212 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cysteine 271 of Probable cytosolic iron-sulfur protein assembly protein CIAO1

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