ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA fragmentation factor subunit beta

Intermolecular
Cysteine 10 and cysteine 78 of DNA fragmentation factor subunit alpha L
Intramolecular
Cysteine 229 and cysteine 238 L
Cysteine 238 and cysteine 307 L
Cysteine 229 and cysteine 307 L
Cysteine 2 and cysteine 29 L
Cysteine 34 and cysteine 47
A redox-regulated disulphide may form between cysteine 10 of DNA fragmentation factor subunit beta and cysteine 78 of DNA fragmentation factor subunit alpha.

Details

Redox score ?
65
PDB code
1f2r
Structure name
nmr structure of the heterodimeric complex between cad domains of cad and icad
Structure deposition date
2000-05-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
32
Peptide A name
DNA fragmentation factor subunit beta
Peptide B name
DNA fragmentation factor subunit alpha
Peptide A accession
O54788
Peptide B accession
O54786
Peptide A residue number
10
Peptide B residue number
78

Ligandability

Cysteine 10 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 78 of DNA fragmentation factor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA fragmentation factor subunit beta between cysteines 229 and 238.

Details

Redox score ?
77
PDB code
1v0d
Structure name
crystal structure of caspase-activated dnase (cad)
Structure deposition date
2004-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O54788
Residue number A
229
Residue number B
238
Peptide name
DNA fragmentation factor subunit beta

Ligandability

Cysteine 229 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 238 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA fragmentation factor subunit beta between cysteines 238 and 307.

Details

Redox score ?
77
PDB code
1v0d
Structure name
crystal structure of caspase-activated dnase (cad)
Structure deposition date
2004-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O54788
Residue number A
238
Residue number B
307
Peptide name
DNA fragmentation factor subunit beta

Ligandability

Cysteine 238 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 307 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA fragmentation factor subunit beta between cysteines 229 and 307.

Details

Redox score ?
76
PDB code
1v0d
Structure name
crystal structure of caspase-activated dnase (cad)
Structure deposition date
2004-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O54788
Residue number A
229
Residue number B
307
Peptide name
DNA fragmentation factor subunit beta

Ligandability

Cysteine 229 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 307 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA fragmentation factor subunit beta between cysteines 2 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1c9f
Structure name
nmr structure of the cad domain of caspase-activated dnase
Structure deposition date
1999-08-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
32
Minimum pKa ?
9
% buried
2
Peptide accession
O54788
Residue number A
2
Residue number B
29
Peptide name
DNA fragmentation factor subunit beta

Ligandability

Cysteine 2 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 29 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA fragmentation factor subunit beta between cysteines 34 and 47. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1ibx
Structure name
nmr structure of dff40 and dff45 n-terminal domain complex
Structure deposition date
2001-03-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
42
Peptide accession
O76075
Residue number A
34
Residue number B
47
Peptide name
DNA fragmentation factor subunit beta

Ligandability

Cysteine 34 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of DNA fragmentation factor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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