Transient receptor potential cation channel subfamily M member 2
Intramolecular
Cysteine 996 and cysteine 1008
Cysteine 327 and cysteine 350
Cysteine 89 and cysteine 91
Cysteine 828 and cysteine 830
Cysteine 811 and cysteine 828
Cysteine 648 and cysteine 693
Cysteine 811 and cysteine 907
Cysteine 693 and cysteine 717
Cysteine 648 and cysteine 717
7vq2 B 996 B 1008
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 996 and 1008.
Details
Redox score ?
85
PDB code
7vq2
Structure name
structure of apo-hstrpm2 channel tm domain
Structure deposition date
2021-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94759
Residue number A
996
Residue number B
1008
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 996 of Transient receptor potential cation channel subfamily M member 2
Cysteine 1008 of Transient receptor potential cation channel subfamily M member 2
6puu C 327 C 350
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 327 and 350.
Details
Redox score ?
70
PDB code
6puu
Structure name
human trpm2 bound to 8-br-cadpr and calcium
Structure deposition date
2019-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
95
Peptide accession
O94759
Residue number A
327
Residue number B
350
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 327 of Transient receptor potential cation channel subfamily M member 2
Cysteine 350 of Transient receptor potential cation channel subfamily M member 2
6miz D 89 D 91
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 89 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6miz
Structure name
human trpm2 ion channel in an adpr-bound state
Structure deposition date
2018-09-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
27
Minimum pKa ?
9
% buried
0
Peptide accession
O94759
Residue number A
89
Residue number B
91
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 89 of Transient receptor potential cation channel subfamily M member 2
Cysteine 91 of Transient receptor potential cation channel subfamily M member 2
6pus A 828 A 830
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 828 and 830. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6pus
Structure name
human trpm2 bound to adpr and calcium
Structure deposition date
2019-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
O94759
Residue number A
828
Residue number B
830
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 828 of Transient receptor potential cation channel subfamily M member 2
Cysteine 830 of Transient receptor potential cation channel subfamily M member 2
6mix C 811 C 828
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 811 and 828. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6mix
Structure name
human trpm2 ion channel in apo state
Structure deposition date
2018-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
3
Peptide accession
O94759
Residue number A
811
Residue number B
828
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 811 of Transient receptor potential cation channel subfamily M member 2
Cysteine 828 of Transient receptor potential cation channel subfamily M member 2
6puu A 648 A 693
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 648 and 693. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6puu
Structure name
human trpm2 bound to 8-br-cadpr and calcium
Structure deposition date
2019-07-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
88
Peptide accession
O94759
Residue number A
648
Residue number B
693
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 648 of Transient receptor potential cation channel subfamily M member 2
Cysteine 693 of Transient receptor potential cation channel subfamily M member 2
6puu C 811 C 907
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 811 and 907. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6puu
Structure name
human trpm2 bound to 8-br-cadpr and calcium
Structure deposition date
2019-07-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
35
Peptide accession
O94759
Residue number A
811
Residue number B
907
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 811 of Transient receptor potential cation channel subfamily M member 2
Cysteine 907 of Transient receptor potential cation channel subfamily M member 2
6mj2 A 693 A 717
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 693 and 717. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6mj2
Structure name
human trpm2 ion channel in a calcium- and adpr-bound state
Structure deposition date
2018-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
98
Peptide accession
O94759
Residue number A
693
Residue number B
717
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 693 of Transient receptor potential cation channel subfamily M member 2
Cysteine 717 of Transient receptor potential cation channel subfamily M member 2
6miz B 648 B 717
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 2 between cysteines 648 and 717. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6miz
Structure name
human trpm2 ion channel in an adpr-bound state
Structure deposition date
2018-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
100
Peptide accession
O94759
Residue number A
648
Residue number B
717
Peptide name
Transient receptor potential cation channel subfamily M member 2
Ligandability
Cysteine 648 of Transient receptor potential cation channel subfamily M member 2
Cysteine 717 of Transient receptor potential cation channel subfamily M member 2
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