ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Intramolecular
Cysteine 274 and cysteine 275
Cysteine 178 and cysteine 222
A redox-regulated disulphide may form within N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 between cysteines 274 and 275 (273 and 274 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2jaj
Structure name
ddah1 complexed with l-257
Structure deposition date
2006-11-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
O94760
Residue number A
274
Residue number B
275
Peptide name
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Ligandability

Cysteine 274 of N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 between cysteines 178 and 222. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
3i4a
Structure name
crystal structure of dimethylarginine dimethylaminohydrolase-1 (ddah- 1) in complex with n5-(1-iminopropyl)-l-ornithine
Structure deposition date
2009-07-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
96
Minimum pKa ?
11
% buried
100
Peptide accession
O94760
Residue number A
178
Residue number B
222
Peptide name
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Ligandability

Cysteine 178 of N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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