ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Contactin-5

Intramolecular
Cysteine 216 and cysteine 268
Cysteine 122 and cysteine 172
Cysteine 410 and cysteine 457
Cysteine 321 and cysteine 368
A redox-regulated disulphide may form within Contactin-5 between cysteines 216 and 268.

Details

Redox score ?
82
PDB code
5e4i
Structure name
crystal structure of mouse cntn5 ig1-ig4 domains
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P68500
Residue number A
216
Residue number B
268
Peptide name
Contactin-5

Ligandability

Cysteine 216 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-5 between cysteines 122 and 172.

Details

Redox score ?
82
PDB code
5e4i
Structure name
crystal structure of mouse cntn5 ig1-ig4 domains
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P68500
Residue number A
122
Residue number B
172
Peptide name
Contactin-5

Ligandability

Cysteine 122 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-5 between cysteines 410 and 457.

Details

Redox score ?
81
PDB code
5e4i
Structure name
crystal structure of mouse cntn5 ig1-ig4 domains
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P68500
Residue number A
410
Residue number B
457
Peptide name
Contactin-5

Ligandability

Cysteine 410 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 457 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-5 between cysteines 321 and 368.

Details

Redox score ?
80
PDB code
5e4i
Structure name
crystal structure of mouse cntn5 ig1-ig4 domains
Structure deposition date
2015-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P68500
Residue number A
321
Residue number B
368
Peptide name
Contactin-5

Ligandability

Cysteine 321 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 368 of Contactin-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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