ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitochondrial import receptor subunit TOM70

Intramolecular
Cysteine 475 and cysteine 502
Cysteine 206 and cysteine 214
A redox-regulated disulphide may form within Mitochondrial import receptor subunit TOM70 between cysteines 475 and 502. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7dhg
Structure name
crystal structure of sars-cov-2 orf9b complex with human tom70
Structure deposition date
2020-11-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
69
Peptide accession
O94826
Residue number A
475
Residue number B
502
Peptide name
Mitochondrial import receptor subunit TOM70

Ligandability

Cysteine 475 of Mitochondrial import receptor subunit TOM70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 502 of Mitochondrial import receptor subunit TOM70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial import receptor subunit TOM70 between cysteines 206 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7kdt
Structure name
human tom70 in complex with sars cov2 orf9b
Structure deposition date
2020-10-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
69
Peptide accession
O94826
Residue number A
206
Residue number B
214
Peptide name
Mitochondrial import receptor subunit TOM70

Ligandability

Cysteine 206 of Mitochondrial import receptor subunit TOM70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of Mitochondrial import receptor subunit TOM70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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