ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

STAGA complex 65 subunit gamma

Intermolecular
Cysteine 173 and cysteine 174 of Transcription initiation factor TFIID subunit 10
Intramolecular
Cysteine 154 and cysteine 190
A redox-regulated disulphide may form between cysteine 173 of STAGA complex 65 subunit gamma and cysteine 174 of Transcription initiation factor TFIID subunit 10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
29
Peptide A name
STAGA complex 65 subunit gamma
Peptide B name
Transcription initiation factor TFIID subunit 10
Peptide A accession
O94864
Peptide B accession
Q12962
Peptide A residue number
173
Peptide B residue number
174

Ligandability

Cysteine 173 of STAGA complex 65 subunit gamma

Cysteine 174 of Transcription initiation factor TFIID subunit 10

A redox-regulated disulphide may form within STAGA complex 65 subunit gamma between cysteines 154 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
96
Peptide accession
O94864
Residue number A
154
Residue number B
190
Peptide name
STAGA complex 65 subunit gamma

Ligandability

Cysteine 154 of STAGA complex 65 subunit gamma

Cysteine 190 of STAGA complex 65 subunit gamma

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