ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SUN domain-containing protein 1

Intermolecular
Cysteine 630 and cysteine 8774 of Nesprin-1
Intramolecular
Cysteine 668 and cysteine 773
A redox-regulated disulphide may form between cysteine 630 of SUN domain-containing protein 1 and cysteine 8774 of Nesprin-1 (657 and 8774 respectively in this structure).

Details

Redox score ?
83
PDB code
6r15
Structure name
crystal structure of the sun1-kash1 6:6 complex
Structure deposition date
2019-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide A name
SUN domain-containing protein 1
Peptide B name
Nesprin-1
Peptide A accession
O94901
Peptide B accession
Q8NF91
Peptide A residue number
630
Peptide B residue number
8774

Ligandability

Cysteine 630 of SUN domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 8774 of Nesprin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SUN domain-containing protein 1 between cysteines 668 and 773 (695 and 800 respectively in this structure).

Details

Redox score ?
63
PDB code
6r16
Structure name
crystal structure of the sun1-kash4 6:6 complex
Structure deposition date
2019-03-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
100
Peptide accession
O94901
Residue number A
668
Residue number B
773
Peptide name
SUN domain-containing protein 1

Ligandability

Cysteine 668 of SUN domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 773 of SUN domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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