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Dickkopf-related protein 1

Intramolecular
Cysteine 195 and cysteine 210
Cysteine 239 and cysteine 263
Cysteine 189 and cysteine 201
Cysteine 220 and cysteine 245
Cysteine 200 and cysteine 237
Cysteine 189 and cysteine 195
Cysteine 189 and cysteine 210
Cysteine 220 and cysteine 239
Cysteine 220 and cysteine 263
Cysteine 195 and cysteine 201
More...
Cysteine 239 and cysteine 245
Cysteine 245 and cysteine 263
Cysteine 201 and cysteine 210
Cysteine 195 and cysteine 200
Cysteine 195 and cysteine 237
Cysteine 200 and cysteine 201
Cysteine 189 and cysteine 200
Cysteine 189 and cysteine 237
Cysteine 210 and cysteine 237
Cysteine 200 and cysteine 210
Cysteine 201 and cysteine 237
Cysteine 237 and cysteine 263
A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 195 and 210.

Details

Redox score ?
87
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
195
Residue number B
210
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 195 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 239 and 263.

Details

Redox score ?
85
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
239
Residue number B
263
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 239 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 189 and 201.

Details

Redox score ?
83
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
189
Residue number B
201
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 189 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 220 and 245.

Details

Redox score ?
82
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
220
Residue number B
245
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 220 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 200 and 237.

Details

Redox score ?
80
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
200
Residue number B
237
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 200 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 189 and 195.

Details

Redox score ?
79
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
189
Residue number B
195
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 189 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 189 and 210.

Details

Redox score ?
74
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
189
Residue number B
210
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 189 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 220 and 239.

Details

Redox score ?
70
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
220
Residue number B
239
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 220 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 220 and 263.

Details

Redox score ?
69
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
220
Residue number B
263
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 220 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 195 and 201.

Details

Redox score ?
69
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
195
Residue number B
201
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 195 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 239 and 245.

Details

Redox score ?
68
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
239
Residue number B
245
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 239 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 245 and 263.

Details

Redox score ?
62
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
245
Residue number B
263
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 245 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 201 and 210.

Details

Redox score ?
61
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
201
Residue number B
210
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 201 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 195 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
195
Residue number B
200
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 195 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 195 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
195
Residue number B
237
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 195 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 200 and 201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
200
Residue number B
201
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 200 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 189 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
189
Residue number B
200
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 189 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 189 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
189
Residue number B
237
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 189 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 210 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
210
Residue number B
237
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 210 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 200 and 210. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
200
Residue number B
210
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 200 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 201 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
201
Residue number B
237
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 201 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dickkopf-related protein 1 between cysteines 237 and 263. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O94907
Residue number A
237
Residue number B
263
Peptide name
Dickkopf-related protein 1

Ligandability

Cysteine 237 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Dickkopf-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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