ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Nuclear factor of activated T-cells 5

Intramolecular
Cysteine 357 and cysteine 384
Cysteine 347 and cysteine 357
Cysteine 347 and cysteine 384
A redox-regulated disulphide may form within Nuclear factor of activated T-cells 5 between cysteines 357 and 384 (281 and 308 respectively in this structure).

Details

Redox score ?
76
PDB code
1imh
Structure name
tonebp/dna complex
Structure deposition date
2001-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
48
Peptide accession
O94916
Residue number A
357
Residue number B
384
Peptide name
Nuclear factor of activated T-cells 5

Ligandability

Cysteine 357 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear factor of activated T-cells 5 between cysteines 347 and 357 (271 and 281 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1imh
Structure name
tonebp/dna complex
Structure deposition date
2001-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
62
Peptide accession
O94916
Residue number A
347
Residue number B
357
Peptide name
Nuclear factor of activated T-cells 5

Ligandability

Cysteine 347 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nuclear factor of activated T-cells 5 between cysteines 347 and 384 (271 and 308 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
1imh
Structure name
tonebp/dna complex
Structure deposition date
2001-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
69
Peptide accession
O94916
Residue number A
347
Residue number B
384
Peptide name
Nuclear factor of activated T-cells 5

Ligandability

Cysteine 347 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Nuclear factor of activated T-cells 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: