ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysine-specific demethylase 4B

Intermolecular
Cysteine 165 and cysteine 165
Intramolecular
Cysteine 235 and cysteine 307
Cysteine 235 and cysteine 309
Cysteine 307 and cysteine 309
A redox-regulated disulphide may form between two units of Lysine-specific demethylase 4B at cysteines 165 and 165.

Details

Redox score ?
83
PDB code
7jm5
Structure name
crystal structure of kdm4b in complex with qc6352
Structure deposition date
2020-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lysine-specific demethylase 4B
Peptide B name
Lysine-specific demethylase 4B
Peptide A accession
O94953
Peptide B accession
O94953
Peptide A residue number
165
Peptide B residue number
165

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4B between cysteines 235 and 307.

Details

Redox score ?
86
PDB code
4lxl
Structure name
crystal structure of jmjd2b complexed with pyridine-2,4-dicarboxylic acid and h3k9me3
Structure deposition date
2013-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
24
Peptide accession
O94953
Residue number A
235
Residue number B
307
Peptide name
Lysine-specific demethylase 4B

Ligandability

Cysteine 235 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4B between cysteines 235 and 309.

Details

Redox score ?
84
PDB code
4lxl
Structure name
crystal structure of jmjd2b complexed with pyridine-2,4-dicarboxylic acid and h3k9me3
Structure deposition date
2013-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
12
Peptide accession
O94953
Residue number A
235
Residue number B
309
Peptide name
Lysine-specific demethylase 4B

Ligandability

Cysteine 235 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4B between cysteines 307 and 309.

Details

Redox score ?
82
PDB code
4lxl
Structure name
crystal structure of jmjd2b complexed with pyridine-2,4-dicarboxylic acid and h3k9me3
Structure deposition date
2013-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
11
Peptide accession
O94953
Residue number A
307
Residue number B
309
Peptide name
Lysine-specific demethylase 4B

Ligandability

Cysteine 307 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Lysine-specific demethylase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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