ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AP-2 complex subunit alpha-2

Intramolecular
Cysteine 491 and cysteine 532
Cysteine 134 and cysteine 171
A redox-regulated disulphide may form within AP-2 complex subunit alpha-2 between cysteines 491 and 532 (492 and 533 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2jkt
Structure name
ap2 clathrin adaptor core with cd4 dileucine peptide rm( phosphos)eikrllse q to e mutant
Structure deposition date
2008-08-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
40
Peptide accession
P17427
Residue number A
491
Residue number B
532
Peptide name
AP-2 complex subunit alpha-2

Ligandability

Cysteine 491 of AP-2 complex subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 532 of AP-2 complex subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AP-2 complex subunit alpha-2 between cysteines 134 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
2jkt
Structure name
ap2 clathrin adaptor core with cd4 dileucine peptide rm( phosphos)eikrllse q to e mutant
Structure deposition date
2008-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
12
% buried
100
Peptide accession
P17427
Residue number A
134
Residue number B
171
Peptide name
AP-2 complex subunit alpha-2

Ligandability

Cysteine 134 of AP-2 complex subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of AP-2 complex subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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