ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Protein transport protein Sec31A

Intramolecular
Cysteine 173 and cysteine 216
Cysteine 279 and cysteine 306
A redox-regulated disulphide may form within Protein transport protein Sec31A between cysteines 173 and 216.

Details

Redox score ?
68
PDB code
7sul
Structure name
crystal structure of the wd-repeat domain of human sec31a
Structure deposition date
2021-11-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
7
% buried
100
Peptide accession
O94979
Residue number A
173
Residue number B
216
Peptide name
Protein transport protein Sec31A

Ligandability

Cysteine 173 of Protein transport protein Sec31A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Protein transport protein Sec31A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein transport protein Sec31A between cysteines 279 and 306.

Details

Redox score ?
62
PDB code
7sul
Structure name
crystal structure of the wd-repeat domain of human sec31a
Structure deposition date
2021-11-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
8
% buried
94
Peptide accession
O94979
Residue number A
279
Residue number B
306
Peptide name
Protein transport protein Sec31A

Ligandability

Cysteine 279 of Protein transport protein Sec31A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Protein transport protein Sec31A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: