a tool for identifying drug-targetable redox-active disulphides

Centrosomal protein of 152 kDa

Intermolecular

Cysteine 1279 and cysteine 1279

A redox-regulated disulphide may form between two units of Centrosomal protein of 152 kDa at cysteines 1279 and 1279 (1223 and 1223 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

the structure of the cep63-cep152 heterotetrameric complex

Structure deposition date

2018-03-21

Thiol separation (Å)

10

Half-sphere exposure sum ?

38

Minimum pK_a ?

9

% buried

6

Peptide A name

Centrosomal protein of 152 kDa

Peptide B name

Centrosomal protein of 152 kDa

Peptide A accession

Peptide B accession

Peptide A residue number

1279

Peptide B residue number

1279

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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