a tool for identifying drug-targetable redox-active disulphides

GTP-binding protein Di-Ras1

Intramolecular

Cysteine 50 and cysteine 55 L

A redox-regulated disulphide may form within GTP-binding protein Di-Ras1 between cysteines 50 and 55.

Details

Redox score ?

82

PDB code

Structure name

the crystal structure of the human diras1 gtpase in the inactive gdp bound state

Structure deposition date

2006-03-21

Thiol separation (Å)

3

Half-sphere exposure sum ?

48

Minimum pK_a ?

9

% buried

13

Peptide accession

Residue number A

50

Residue number B

55

Peptide name

GTP-binding protein Di-Ras1

Ligandability

Cysteine 50 of GTP-binding protein Di-Ras1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of GTP-binding protein Di-Ras1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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