ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sphingosine 1-phosphate receptor 2

Intramolecular
Cysteine 259 and cysteine 264
Cysteine 172 and cysteine 179
Cysteine 44 and cysteine 45
A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 2 between cysteines 259 and 264.

Details

Redox score ?
88
PDB code
7t6b
Structure name
structure of s1pr2-heterotrimeric g13 signaling complex
Structure deposition date
2021-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95136
Residue number A
259
Residue number B
264
Peptide name
Sphingosine 1-phosphate receptor 2

Ligandability

Cysteine 259 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 2 between cysteines 172 and 179.

Details

Redox score ?
85
PDB code
7t6b
Structure name
structure of s1pr2-heterotrimeric g13 signaling complex
Structure deposition date
2021-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95136
Residue number A
172
Residue number B
179
Peptide name
Sphingosine 1-phosphate receptor 2

Ligandability

Cysteine 172 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 2 between cysteines 44 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7t6b
Structure name
structure of s1pr2-heterotrimeric g13 signaling complex
Structure deposition date
2021-12-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
30
Peptide accession
O95136
Residue number A
44
Residue number B
45
Peptide name
Sphingosine 1-phosphate receptor 2

Ligandability

Cysteine 44 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Sphingosine 1-phosphate receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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