ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Snurportin-1

Intermolecular
Cysteine 723 of Exportin-1 and cysteine 356
Intramolecular
Cysteine 190 and cysteine 199
A redox-regulated disulphide may form between cysteine 723 of Exportin-1 and cysteine 356 of Snurportin-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
3nc0
Structure name
crystal structure of the hiv-1 rev nes-crm1-rangtp nuclear export complex (crystal ii)
Structure deposition date
2010-06-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
78
Peptide A name
Exportin-1
Peptide B name
Snurportin-1
Peptide A accession
Q6P5F9
Peptide B accession
O95149
Peptide A residue number
723
Peptide B residue number
356

Ligandability

Cysteine 723 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Snurportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Snurportin-1 between cysteines 190 and 199 (189 and 198 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3nby
Structure name
crystal structure of the pki nes-crm1-rangtp nuclear export complex
Structure deposition date
2010-06-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
75
Peptide accession
O95149
Residue number A
190
Residue number B
199
Peptide name
Snurportin-1

Ligandability

Cysteine 190 of Snurportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Snurportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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