ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Kinesin-like protein KIF20A

Intermolecular
Cysteine 607 and cysteine 607
Intramolecular
Cysteine 86 and cysteine 486
Cysteine 86 and cysteine 88
A redox-regulated disulphide may form between two units of Kinesin-like protein KIF20A at cysteines 607 and 607.

Details

Redox score ?
86
PDB code
6yip
Structure name
structure of mklp2 coiled coil
Structure deposition date
2020-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Kinesin-like protein KIF20A
Peptide B name
Kinesin-like protein KIF20A
Peptide A accession
O95235
Peptide B accession
O95235
Peptide A residue number
607
Peptide B residue number
607

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin-like protein KIF20A between cysteines 86 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5nd7
Structure name
microtubule-bound mklp2 motor domain in the presence of amppnp
Structure deposition date
2017-03-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
38
Peptide accession
P97329
Residue number A
86
Residue number B
486
Peptide name
Kinesin-like protein KIF20A

Ligandability

Cysteine 86 of Kinesin-like protein KIF20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Kinesin-like protein KIF20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin-like protein KIF20A between cysteines 86 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5nd4
Structure name
microtubule-bound mklp2 motor domain in the presence of adp
Structure deposition date
2017-03-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
40
Peptide accession
P97329
Residue number A
86
Residue number B
88
Peptide name
Kinesin-like protein KIF20A

Ligandability

Cysteine 86 of Kinesin-like protein KIF20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Kinesin-like protein KIF20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: