a tool for identifying drug-targetable redox-active disulphides

Methyl-CpG-binding domain protein 4

Intramolecular

Cysteine 82 and cysteine 88 L

A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 4 between cysteines 82 and 88.

Details

Redox score ?

67

PDB code

Structure name

solution structure of mbd4 methyl-cytosine binding domain bound to methylated dna

Structure deposition date

2014-04-24

Thiol separation (Å)

6

Half-sphere exposure sum ?

28

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

82

Residue number B

88

Peptide name

Methyl-CpG-binding domain protein 4

Ligandability

Cysteine 82 of Methyl-CpG-binding domain protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Methyl-CpG-binding domain protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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