ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-18 receptor accessory protein

Intramolecular
Cysteine 175 and cysteine 221
Cysteine 155 and cysteine 180
Cysteine 46 and cysteine 109
Cysteine 273 and cysteine 337
Cysteine 46 and cysteine 126
Cysteine 109 and cysteine 126
A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 175 and 221.

Details

Redox score ?
90
PDB code
6kn9
Structure name
crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scfv
Structure deposition date
2018-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95256
Residue number A
175
Residue number B
221
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 175 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 155 and 180.

Details

Redox score ?
87
PDB code
3wo4
Structure name
crystal structure of the il-18 signaling ternary complex
Structure deposition date
2013-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95256
Residue number A
155
Residue number B
180
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 155 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 46 and 109.

Details

Redox score ?
83
PDB code
6kn9
Structure name
crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scfv
Structure deposition date
2018-05-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
0
Peptide accession
O95256
Residue number A
46
Residue number B
109
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 46 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 273 and 337.

Details

Redox score ?
81
PDB code
6kn9
Structure name
crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scfv
Structure deposition date
2018-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95256
Residue number A
273
Residue number B
337
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 273 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 46 and 126.

Details

Redox score ?
75
PDB code
6kn9
Structure name
crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scfv
Structure deposition date
2018-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
0
Peptide accession
O95256
Residue number A
46
Residue number B
126
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 46 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 receptor accessory protein between cysteines 109 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6kn9
Structure name
crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scfv
Structure deposition date
2018-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
0
Peptide accession
O95256
Residue number A
109
Residue number B
126
Peptide name
Interleukin-18 receptor accessory protein

Ligandability

Cysteine 109 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Interleukin-18 receptor accessory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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