ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RAS guanyl-releasing protein 1

Intramolecular
Cysteine 572 and cysteine 591
Cysteine 572 and cysteine 575
Cysteine 555 and cysteine 583
Cysteine 555 and cysteine 558
Cysteine 575 and cysteine 591
Cysteine 555 and cysteine 579
Cysteine 558 and cysteine 583
Cysteine 572 and cysteine 579
Cysteine 579 and cysteine 583
Cysteine 558 and cysteine 579
More...
Cysteine 122 and cysteine 126
Cysteine 126 and cysteine 166
Cysteine 575 and cysteine 579
A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 572 and 591.

Details

Redox score ?
91
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
5
% buried
4
Peptide accession
O95267
Residue number A
572
Residue number B
591
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 572 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 591 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 572 and 575.

Details

Redox score ?
91
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
10
Peptide accession
O95267
Residue number A
572
Residue number B
575
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 572 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 575 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 555 and 583.

Details

Redox score ?
84
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
38
Peptide accession
O95267
Residue number A
555
Residue number B
583
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 555 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 555 and 558.

Details

Redox score ?
84
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
26
Peptide accession
O95267
Residue number A
555
Residue number B
558
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 555 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 575 and 591.

Details

Redox score ?
81
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
6
Peptide accession
O95267
Residue number A
575
Residue number B
591
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 575 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 591 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 555 and 579.

Details

Redox score ?
76
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
48
Peptide accession
O95267
Residue number A
555
Residue number B
579
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 555 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 579 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 558 and 583.

Details

Redox score ?
75
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
22
Peptide accession
O95267
Residue number A
558
Residue number B
583
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 558 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 572 and 579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
5
% buried
32
Peptide accession
O95267
Residue number A
572
Residue number B
579
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 572 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 579 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 579 and 583. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
44
Peptide accession
O95267
Residue number A
579
Residue number B
583
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 579 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 558 and 579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
32
Peptide accession
O95267
Residue number A
558
Residue number B
579
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 558 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 579 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 122 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
62
Peptide accession
O95267
Residue number A
122
Residue number B
126
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 122 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 126 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
49
Peptide accession
O95267
Residue number A
126
Residue number B
166
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 126 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAS guanyl-releasing protein 1 between cysteines 575 and 579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4l9m
Structure name
autoinhibited state of the ras-specific exchange factor rasgrp1
Structure deposition date
2013-06-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
34
Peptide accession
O95267
Residue number A
575
Residue number B
579
Peptide name
RAS guanyl-releasing protein 1

Ligandability

Cysteine 575 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 579 of RAS guanyl-releasing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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