ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CUGBP Elav-like family member 2

Intramolecular
Cysteine 143 and cysteine 201
Cysteine 85 and cysteine 86
A redox-regulated disulphide may form within CUGBP Elav-like family member 2 between cysteines 143 and 201 (108 and 166 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4lmz
Structure name
structural insight into rna recognition by rrm1+2 domain of human etr- 3 protein
Structure deposition date
2013-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
23
Peptide accession
O95319
Residue number A
143
Residue number B
201
Peptide name
CUGBP Elav-like family member 2

Ligandability

Cysteine 143 of CUGBP Elav-like family member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of CUGBP Elav-like family member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CUGBP Elav-like family member 2 between cysteines 85 and 86 (50 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4lmz
Structure name
structural insight into rna recognition by rrm1+2 domain of human etr- 3 protein
Structure deposition date
2013-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
51
Peptide accession
O95319
Residue number A
85
Residue number B
86
Peptide name
CUGBP Elav-like family member 2

Ligandability

Cysteine 85 of CUGBP Elav-like family member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of CUGBP Elav-like family member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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