a tool for identifying drug-targetable redox-active disulphides

Bile salt export pump

Intramolecular

Cysteine 331 and cysteine 807

A redox-regulated disulphide may form within Bile salt export pump between cysteines 331 and 807.

Details

Redox score ?

63

PDB code

Structure name

structure of human bile salt exporter abcb11

Structure deposition date

2020-01-15

Thiol separation (Å)

6

Half-sphere exposure sum ?

55

Minimum pK_a ?

9

% buried

14

Peptide accession

Residue number A

331

Residue number B

807

Peptide name

Bile salt export pump

Ligandability

Cysteine 331 of Bile salt export pump

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 807 of Bile salt export pump

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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