a tool for identifying drug-targetable redox-active disulphides

Phenylalanine--tRNA ligase, mitochondrial

Intramolecular

Cysteine 266 and cysteine 291

A redox-regulated disulphide may form within Phenylalanine--tRNA ligase, mitochondrial between cysteines 266 and 291 (230 and 255 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

crystal structure of human mitochondrial phenylalanine trna synthetase

Structure deposition date

2008-03-24

Thiol separation (Å)

7

Half-sphere exposure sum ?

67

Minimum pK_a ?

11

% buried

78

Peptide accession

Residue number A

266

Residue number B

291

Peptide name

Phenylalanine--tRNA ligase, mitochondrial

Ligandability

Cysteine 266 of Phenylalanine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Phenylalanine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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