ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger and BTB domain-containing protein 7A

Intermolecular
Cysteine 468 and cysteine 387
Cysteine 443 and cysteine 443
Intramolecular
Cysteine 468 and cysteine 490
Cysteine 468 and cysteine 471
Cysteine 412 and cysteine 415
Cysteine 440 and cysteine 443
Cysteine 384 and cysteine 387
Cysteine 471 and cysteine 490
Cysteine 471 and cysteine 472
Cysteine 468 and cysteine 472
More...
Cysteine 472 and cysteine 490
Cysteine 440 and cysteine 472
A redox-regulated disulphide may form between two units of Zinc finger and BTB domain-containing protein 7A at cysteines 468 and 387. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7n5v
Structure name
zbtb7a zinc finger domain bound to dna duplex containing ggaccc (oligo 20)
Structure deposition date
2021-06-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
7
% buried
53
Peptide A name
Zinc finger and BTB domain-containing protein 7A
Peptide B name
Zinc finger and BTB domain-containing protein 7A
Peptide A accession
O95365
Peptide B accession
O95365
Peptide A residue number
468
Peptide B residue number
387

Ligandability

Cysteine 468 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Zinc finger and BTB domain-containing protein 7A at cysteines 443 and 443. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
8e3e
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#10)
Structure deposition date
2022-08-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
56
Peptide A name
Zinc finger and BTB domain-containing protein 7A
Peptide B name
Zinc finger and BTB domain-containing protein 7A
Peptide A accession
O95365
Peptide B accession
O95365
Peptide A residue number
443
Peptide B residue number
443

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 468 and 490.

Details

Redox score ?
95
PDB code
8e3e
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#10)
Structure deposition date
2022-08-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
0
Peptide accession
O95365
Residue number A
468
Residue number B
490
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 468 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 468 and 471.

Details

Redox score ?
94
PDB code
8e3e
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#10)
Structure deposition date
2022-08-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
0
Peptide accession
O95365
Residue number A
468
Residue number B
471
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 468 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 412 and 415.

Details

Redox score ?
91
PDB code
8e3d
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#11)
Structure deposition date
2022-08-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
O95365
Residue number A
412
Residue number B
415
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 412 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 440 and 443.

Details

Redox score ?
89
PDB code
8e3e
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#10)
Structure deposition date
2022-08-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
46
Peptide accession
O95365
Residue number A
440
Residue number B
443
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 440 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 443 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 384 and 387.

Details

Redox score ?
89
PDB code
7n5v
Structure name
zbtb7a zinc finger domain bound to dna duplex containing ggaccc (oligo 20)
Structure deposition date
2021-06-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
26
Peptide accession
O95365
Residue number A
384
Residue number B
387
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 384 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 471 and 490.

Details

Redox score ?
81
PDB code
8e3e
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#10)
Structure deposition date
2022-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
8
% buried
2
Peptide accession
O95365
Residue number A
471
Residue number B
490
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 471 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 471 and 472.

Details

Redox score ?
70
PDB code
8e3d
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#11)
Structure deposition date
2022-08-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
30
Minimum pKa ?
8
% buried
0
Peptide accession
O95365
Residue number A
471
Residue number B
472
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 471 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 468 and 472.

Details

Redox score ?
60
PDB code
8e3d
Structure name
zbtb7a zinc finger domain bound to dna duplex containing cast sequence (#11)
Structure deposition date
2022-08-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
O95365
Residue number A
468
Residue number B
472
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 468 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 472 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7eyi
Structure name
crystal structure of zbtb7a in complex with gamma-globin -200 sequence element with c-194a mutation
Structure deposition date
2021-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
O95365
Residue number A
472
Residue number B
490
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 472 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 7A between cysteines 440 and 472. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7n5v
Structure name
zbtb7a zinc finger domain bound to dna duplex containing ggaccc (oligo 20)
Structure deposition date
2021-06-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
22
Peptide accession
O95365
Residue number A
440
Residue number B
472
Peptide name
Zinc finger and BTB domain-containing protein 7A

Ligandability

Cysteine 440 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Zinc finger and BTB domain-containing protein 7A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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