ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pre-mRNA-splicing factor SLU7

Intramolecular
Cysteine 120 and cysteine 123
Cysteine 120 and cysteine 133
Cysteine 123 and cysteine 133
A redox-regulated disulphide may form within Pre-mRNA-splicing factor SLU7 between cysteines 120 and 123.

Details

Redox score ?
74
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
64
Peptide accession
O95391
Residue number A
120
Residue number B
123
Peptide name
Pre-mRNA-splicing factor SLU7

Ligandability

Cysteine 120 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor SLU7 between cysteines 120 and 133.

Details

Redox score ?
69
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
nan
Peptide accession
O95391
Residue number A
120
Residue number B
133
Peptide name
Pre-mRNA-splicing factor SLU7

Ligandability

Cysteine 120 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor SLU7 between cysteines 123 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
19
% buried
nan
Peptide accession
O95391
Residue number A
123
Residue number B
133
Peptide name
Pre-mRNA-splicing factor SLU7

Ligandability

Cysteine 123 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Pre-mRNA-splicing factor SLU7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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