Bone morphogenetic protein 10
Intermolecular
Cysteine 388 and cysteine 388
Intramolecular
Cysteine 323 and cysteine 389
Cysteine 352 and cysteine 421
Cysteine 356 and cysteine 423
Cysteine 323 and cysteine 356
Cysteine 323 and cysteine 423
Cysteine 352 and cysteine 389
Cysteine 356 and cysteine 389
Cysteine 389 and cysteine 421
Cysteine 323 and cysteine 421
More...Cysteine 323 and cysteine 352
Cysteine 389 and cysteine 423
Cysteine 356 and cysteine 388
Cysteine 388 and cysteine 389
Cysteine 323 and cysteine 388
Cysteine 352 and cysteine 356
Cysteine 421 and cysteine 423
Cysteine 356 and cysteine 421
Cysteine 352 and cysteine 423
Cysteine 388 and cysteine 423
Cysteine 352 and cysteine 388
7ppc A 388 B 388
A redox-regulated disulphide may form between two units of Bone morphogenetic protein 10 at cysteines 388 and 388.
Details
Redox score ?
74
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 10
Peptide B name
Bone morphogenetic protein 10
Peptide A accession
O95393
Peptide B accession
O95393
Peptide A residue number
388
Peptide B residue number
388
Ligandability
7poi B 323 B 389
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 389.
Details
Redox score ?
85
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
389
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 389 of Bone morphogenetic protein 10
7poi A 352 A 421
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 352 and 421.
Details
Redox score ?
84
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
352
Residue number B
421
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 352 of Bone morphogenetic protein 10
Cysteine 421 of Bone morphogenetic protein 10
7poi A 356 A 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 356 and 423.
Details
Redox score ?
83
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
356
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 356 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7ppa B 323 B 356
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 356.
Details
Redox score ?
74
PDB code
7ppa
Structure name
high resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
356
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 356 of Bone morphogenetic protein 10
7ppa B 323 B 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 423.
Details
Redox score ?
72
PDB code
7ppa
Structure name
high resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7ppb A 352 A 389
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 352 and 389.
Details
Redox score ?
70
PDB code
7ppb
Structure name
2
Structure deposition date
2021-09-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
352
Residue number B
389
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 352 of Bone morphogenetic protein 10
Cysteine 389 of Bone morphogenetic protein 10
6sf3 B 356 B 389
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 356 and 389.
Details
Redox score ?
69
PDB code
6sf3
Structure name
bone morphogenetic protein 10 (bmp10) in complex with extracellular domain of activin receptor-like kinase 1 (alk1) at 2
Structure deposition date
2019-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
356
Residue number B
389
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 356 of Bone morphogenetic protein 10
Cysteine 389 of Bone morphogenetic protein 10
7ppc B 389 B 421
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 389 and 421.
Details
Redox score ?
66
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
389
Residue number B
421
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 389 of Bone morphogenetic protein 10
Cysteine 421 of Bone morphogenetic protein 10
7ppc D 323 D 421
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 421.
Details
Redox score ?
66
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
421
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 421 of Bone morphogenetic protein 10
7ppa B 323 B 352
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 352.
Details
Redox score ?
65
PDB code
7ppa
Structure name
high resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Structure deposition date
2021-09-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
352
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 352 of Bone morphogenetic protein 10
7poi A 389 A 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 389 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
389
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 389 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7poi B 356 B 388
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 356 and 388. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
356
Residue number B
388
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 356 of Bone morphogenetic protein 10
Cysteine 388 of Bone morphogenetic protein 10
7ppa B 388 B 389
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 388 and 389. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7ppa
Structure name
high resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Structure deposition date
2021-09-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
388
Residue number B
389
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 388 of Bone morphogenetic protein 10
Cysteine 389 of Bone morphogenetic protein 10
7ppa B 323 B 388
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 323 and 388. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7ppa
Structure name
high resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Structure deposition date
2021-09-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
323
Residue number B
388
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 323 of Bone morphogenetic protein 10
Cysteine 388 of Bone morphogenetic protein 10
6sf3 B 352 B 356
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 352 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6sf3
Structure name
bone morphogenetic protein 10 (bmp10) in complex with extracellular domain of activin receptor-like kinase 1 (alk1) at 2
Structure deposition date
2019-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
352
Residue number B
356
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 352 of Bone morphogenetic protein 10
Cysteine 356 of Bone morphogenetic protein 10
7ppc C 421 C 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 421 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
421
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 421 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7poj A 356 A 421
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 356 and 421. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7poj
Structure name
prodomain bound bmp10 crystal form 2
Structure deposition date
2021-09-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
356
Residue number B
421
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 356 of Bone morphogenetic protein 10
Cysteine 421 of Bone morphogenetic protein 10
7ppc A 352 A 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 352 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
352
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 352 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7poi B 388 B 423
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 388 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7poi
Structure name
prodomain bound bmp10 crystal form 1
Structure deposition date
2021-09-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
388
Residue number B
423
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 388 of Bone morphogenetic protein 10
Cysteine 423 of Bone morphogenetic protein 10
7ppc C 352 C 388
A redox-regulated disulphide may form within Bone morphogenetic protein 10 between cysteines 352 and 388. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95393
Residue number A
352
Residue number B
388
Peptide name
Bone morphogenetic protein 10
Ligandability
Cysteine 352 of Bone morphogenetic protein 10
Cysteine 388 of Bone morphogenetic protein 10
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