ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Apolipoprotein M

Intramolecular
Cysteine 95 and cysteine 183
Cysteine 23 and cysteine 167
Cysteine 128 and cysteine 157
A redox-regulated disulphide may form within Apolipoprotein M between cysteines 95 and 183.

Details

Redox score ?
87
PDB code
2wex
Structure name
crystal structure of human apom in complex with glycerol 1- myristic acid
Structure deposition date
2009-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95445
Residue number A
95
Residue number B
183
Peptide name
Apolipoprotein M

Ligandability

Cysteine 95 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Apolipoprotein M between cysteines 23 and 167.

Details

Redox score ?
86
PDB code
2wew
Structure name
crystal structure of human apom in complex with myristic acid
Structure deposition date
2009-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95445
Residue number A
23
Residue number B
167
Peptide name
Apolipoprotein M

Ligandability

Cysteine 23 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Apolipoprotein M between cysteines 128 and 157.

Details

Redox score ?
81
PDB code
2wex
Structure name
crystal structure of human apom in complex with glycerol 1- myristic acid
Structure deposition date
2009-04-02
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
32
Peptide accession
O95445
Residue number A
128
Residue number B
157
Peptide name
Apolipoprotein M

Ligandability

Cysteine 128 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of Apolipoprotein M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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