ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Poly(A)-specific ribonuclease PARN

Intermolecular
Cysteine 108 and cysteine 108
Intramolecular
Cysteine 302 and cysteine 317
A redox-regulated disulphide may form between two units of Poly(A)-specific ribonuclease PARN at cysteines 108 and 108.

Details

Redox score ?
69
PDB code
3d45
Structure name
crystal structure of mouse parn in complex with m7gpppg
Structure deposition date
2008-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
100
Peptide A name
Poly(A)-specific ribonuclease PARN
Peptide B name
Poly(A)-specific ribonuclease PARN
Peptide A accession
Q8VDG3
Peptide B accession
Q8VDG3
Peptide A residue number
108
Peptide B residue number
108

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly(A)-specific ribonuclease PARN between cysteines 302 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2a1s
Structure name
crystal structure of native parn nuclease domain
Structure deposition date
2005-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
20
Peptide accession
O95453
Residue number A
302
Residue number B
317
Peptide name
Poly(A)-specific ribonuclease PARN

Ligandability

Cysteine 302 of Poly(A)-specific ribonuclease PARN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Poly(A)-specific ribonuclease PARN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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