Protein transport protein Sec24A
Intramolecular
Cysteine 434 and cysteine 455
Cysteine 434 and cysteine 452
Cysteine 431 and cysteine 455
Cysteine 431 and cysteine 452
Cysteine 431 and cysteine 434
Cysteine 452 and cysteine 455
Cysteine 434 and cysteine 753
Cysteine 704 and cysteine 928
Cysteine 381 and cysteine 824
Cysteine 388 and cysteine 753
5vnk B 434 B 455
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 434 and 455.
Details
Redox score ?
88
PDB code
5vnk
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with a c-terminal ll sorting motif
Structure deposition date
2017-04-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
3
% buried
44
Peptide accession
O95486
Residue number A
434
Residue number B
455
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 434 of Protein transport protein Sec24A
Cysteine 455 of Protein transport protein Sec24A
2nup B 434 B 452
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 434 and 452.
Details
Redox score ?
88
PDB code
2nup
Structure name
crystal structure of the human sec23a/24a heterodimer, complexed with the snare protein sec22b
Structure deposition date
2006-11-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
3
% buried
59
Peptide accession
O95486
Residue number A
434
Residue number B
452
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 434 of Protein transport protein Sec24A
Cysteine 452 of Protein transport protein Sec24A
5vnk B 431 B 455
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 431 and 455.
Details
Redox score ?
84
PDB code
5vnk
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with a c-terminal ll sorting motif
Structure deposition date
2017-04-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
34
Peptide accession
O95486
Residue number A
431
Residue number B
455
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 431 of Protein transport protein Sec24A
Cysteine 455 of Protein transport protein Sec24A
5vng B 431 B 452
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 431 and 452.
Details
Redox score ?
82
PDB code
5vng
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with a c-terminal ii sorting motif
Structure deposition date
2017-04-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
50
Peptide accession
O95486
Residue number A
431
Residue number B
452
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 431 of Protein transport protein Sec24A
Cysteine 452 of Protein transport protein Sec24A
3egd B 431 B 434
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 431 and 434.
Details
Redox score ?
79
PDB code
3egd
Structure name
crystal structure of the mammalian copii-coat protein sec23a/24a complexed with the snare protein sec22 and bound to the transport signal sequence of vesicular stomatitis virus glycoprotein
Structure deposition date
2008-09-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
nan
Peptide accession
O95486
Residue number A
431
Residue number B
434
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 431 of Protein transport protein Sec24A
Cysteine 434 of Protein transport protein Sec24A
5vnj B 452 B 455
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 452 and 455.
Details
Redox score ?
73
PDB code
5vnj
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with a c-terminal ff sorting motif (ergic-53)
Structure deposition date
2017-04-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
50
Peptide accession
O95486
Residue number A
452
Residue number B
455
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 452 of Protein transport protein Sec24A
Cysteine 455 of Protein transport protein Sec24A
5vnf B 434 B 753
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 434 and 753. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
5vnf
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with a c-terminal vv sorting motif
Structure deposition date
2017-04-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
3
% buried
74
Peptide accession
O95486
Residue number A
434
Residue number B
753
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 434 of Protein transport protein Sec24A
Cysteine 753 of Protein transport protein Sec24A
5vnl B 704 B 928
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 704 and 928. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5vnl
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with 4- phenylbutyric acid (1mm soaking)
Structure deposition date
2017-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
90
Peptide accession
O95486
Residue number A
704
Residue number B
928
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 704 of Protein transport protein Sec24A
Cysteine 928 of Protein transport protein Sec24A
5vne B 381 B 824
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 381 and 824. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
5vne
Structure name
crystal structure of sec23a/sec24a/sec22 complexed with emp24 sorting motif
Structure deposition date
2017-04-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
O95486
Residue number A
381
Residue number B
824
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 381 of Protein transport protein Sec24A
Cysteine 824 of Protein transport protein Sec24A
2nup B 388 B 753
A redox-regulated disulphide may form within Protein transport protein Sec24A between cysteines 388 and 753. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
2nup
Structure name
crystal structure of the human sec23a/24a heterodimer, complexed with the snare protein sec22b
Structure deposition date
2006-11-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
O95486
Residue number A
388
Residue number B
753
Peptide name
Protein transport protein Sec24A
Ligandability
Cysteine 388 of Protein transport protein Sec24A
Cysteine 753 of Protein transport protein Sec24A
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