ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein transport protein Sec24B

Intramolecular
Cysteine 605 and cysteine 608
Cysteine 608 and cysteine 626
Cysteine 608 and cysteine 629
Cysteine 605 and cysteine 626
Cysteine 605 and cysteine 629
Cysteine 626 and cysteine 629
Cysteine 608 and cysteine 928
Cysteine 608 and cysteine 977
Cysteine 977 and cysteine 999
Cysteine 879 and cysteine 1103
More...
Cysteine 626 and cysteine 977
Cysteine 555 and cysteine 977
Cysteine 928 and cysteine 977
A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 605 and 608.

Details

Redox score ?
89
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
3
% buried
46
Peptide accession
O95487
Residue number A
605
Residue number B
608
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 605 of Protein transport protein Sec24B

Cysteine 608 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 608 and 626.

Details

Redox score ?
87
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
3
% buried
62
Peptide accession
O95487
Residue number A
608
Residue number B
626
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 608 of Protein transport protein Sec24B

Cysteine 626 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 608 and 629.

Details

Redox score ?
83
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
3
% buried
44
Peptide accession
O95487
Residue number A
608
Residue number B
629
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 608 of Protein transport protein Sec24B

Cysteine 629 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 605 and 626.

Details

Redox score ?
82
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
51
Peptide accession
O95487
Residue number A
605
Residue number B
626
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 605 of Protein transport protein Sec24B

Cysteine 626 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 605 and 629.

Details

Redox score ?
81
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
34
Peptide accession
O95487
Residue number A
605
Residue number B
629
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 605 of Protein transport protein Sec24B

Cysteine 629 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 626 and 629.

Details

Redox score ?
69
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
48
Peptide accession
O95487
Residue number A
626
Residue number B
629
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 626 of Protein transport protein Sec24B

Cysteine 629 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 608 and 928. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
3
% buried
78
Peptide accession
O95487
Residue number A
608
Residue number B
928
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 608 of Protein transport protein Sec24B

Cysteine 928 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 608 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
3
% buried
78
Peptide accession
O95487
Residue number A
608
Residue number B
977
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 608 of Protein transport protein Sec24B

Cysteine 977 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 977 and 999. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
91
Peptide accession
O95487
Residue number A
977
Residue number B
999
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 977 of Protein transport protein Sec24B

Cysteine 999 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 879 and 1103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
92
Peptide accession
O95487
Residue number A
879
Residue number B
1103
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 879 of Protein transport protein Sec24B

Cysteine 1103 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 626 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
14
% buried
83
Peptide accession
O95487
Residue number A
626
Residue number B
977
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 626 of Protein transport protein Sec24B

Cysteine 977 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 555 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
O95487
Residue number A
555
Residue number B
977
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 555 of Protein transport protein Sec24B

Cysteine 977 of Protein transport protein Sec24B

A redox-regulated disulphide may form within Protein transport protein Sec24B between cysteines 928 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3eh1
Structure name
crystal structure of the human copii-coat protein sec24b
Structure deposition date
2008-09-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
99
Peptide accession
O95487
Residue number A
928
Residue number B
977
Peptide name
Protein transport protein Sec24B

Ligandability

Cysteine 928 of Protein transport protein Sec24B

Cysteine 977 of Protein transport protein Sec24B

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