DNA-directed RNA polymerase I subunit RPA1
Intermolecular
Cysteine 67 and cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 67 and cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 968 and cysteine 498 of DNA-directed RNA polymerase I subunit RPA2
Cysteine 539 and cysteine 1061 of DNA-directed RNA polymerase I subunit RPA2 L
Cysteine 968 and cysteine 689 of DNA-directed RNA polymerase I subunit RPA2
Intramolecular
Cysteine 104 and cysteine 205
Cysteine 107 and cysteine 208
Cysteine 205 and cysteine 208
Cysteine 104 and cysteine 107
Cysteine 64 and cysteine 67
More...Cysteine 107 and cysteine 205
Cysteine 104 and cysteine 208
Cysteine 64 and cysteine 74
Cysteine 880 and cysteine 914
Cysteine 67 and cysteine 74
Cysteine 733 and cysteine 746 L
Cysteine 112 and cysteine 205
Cysteine 104 and cysteine 112
Cysteine 764 and cysteine 765
8a43 A 67 B 1098
A redox-regulated disulphide may form between cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2.
Details
Redox score ?
62
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
60
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
67
Peptide B residue number
1098
Ligandability
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1098 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 67 B 1070
A redox-regulated disulphide may form between cysteine 67 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
59
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
67
Peptide B residue number
1070
Ligandability
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1070 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 968 B 498
A redox-regulated disulphide may form between cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 498 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
968
Peptide B residue number
498
Ligandability
Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 498 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 539 B 1061
A redox-regulated disulphide may form between cysteine 539 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 1061 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
539
Peptide B residue number
1061
Ligandability
Cysteine 539 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 1061 of DNA-directed RNA polymerase I subunit RPA2
7ob9 A 968 B 689
A redox-regulated disulphide may form between cysteine 968 of DNA-directed RNA polymerase I subunit RPA1 and cysteine 689 of DNA-directed RNA polymerase I subunit RPA2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide A name
DNA-directed RNA polymerase I subunit RPA1
Peptide B name
DNA-directed RNA polymerase I subunit RPA2
Peptide A accession
O95602
Peptide B accession
Q9H9Y6
Peptide A residue number
968
Peptide B residue number
689
Ligandability
Cysteine 968 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 689 of DNA-directed RNA polymerase I subunit RPA2
8a43 A 104 A 205
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 104 and 205.
Details
Redox score ?
82
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
40
Peptide accession
O95602
Residue number A
104
Residue number B
205
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 104 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 205 of DNA-directed RNA polymerase I subunit RPA1
7obb A 107 A 208
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 107 and 208.
Details
Redox score ?
82
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
5
Peptide accession
O95602
Residue number A
107
Residue number B
208
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 107 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 208 of DNA-directed RNA polymerase I subunit RPA1
7oba A 205 A 208
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 205 and 208.
Details
Redox score ?
78
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
6
Peptide accession
O95602
Residue number A
205
Residue number B
208
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 205 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 208 of DNA-directed RNA polymerase I subunit RPA1
7oba A 104 A 107
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 104 and 107.
Details
Redox score ?
74
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
29
Peptide accession
O95602
Residue number A
104
Residue number B
107
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 104 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 107 of DNA-directed RNA polymerase I subunit RPA1
8a43 A 64 A 67
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 64 and 67.
Details
Redox score ?
70
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
66
Peptide accession
O95602
Residue number A
64
Residue number B
67
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 64 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
8a43 A 107 A 205
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 107 and 205.
Details
Redox score ?
66
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
14
Peptide accession
O95602
Residue number A
107
Residue number B
205
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 107 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 205 of DNA-directed RNA polymerase I subunit RPA1
7oba A 104 A 208
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 104 and 208.
Details
Redox score ?
65
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
18
Peptide accession
O95602
Residue number A
104
Residue number B
208
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 104 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 208 of DNA-directed RNA polymerase I subunit RPA1
7obb A 64 A 74
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 64 and 74.
Details
Redox score ?
65
PDB code
7obb
Structure name
cryo-em structure of human rna polymerase i open complex
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
nan
Peptide accession
O95602
Residue number A
64
Residue number B
74
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 64 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 74 of DNA-directed RNA polymerase I subunit RPA1
8a43 A 880 A 914
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 880 and 914.
Details
Redox score ?
62
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
63
Peptide accession
O95602
Residue number A
880
Residue number B
914
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 880 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 914 of DNA-directed RNA polymerase I subunit RPA1
7oba A 67 A 74
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 67 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
18
% buried
nan
Peptide accession
O95602
Residue number A
67
Residue number B
74
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 67 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 74 of DNA-directed RNA polymerase I subunit RPA1
7ob9 A 733 A 746
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 733 and 746. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ob9
Structure name
cryo-em structure of human rna polymerase i in elongation state
Structure deposition date
2021-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
90
Peptide accession
O95602
Residue number A
733
Residue number B
746
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 733 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 746 of DNA-directed RNA polymerase I subunit RPA1
8a43 A 112 A 205
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 112 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
38
Peptide accession
O95602
Residue number A
112
Residue number B
205
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 112 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 205 of DNA-directed RNA polymerase I subunit RPA1
8a43 A 104 A 112
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 104 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
8a43
Structure name
human rna polymerase i
Structure deposition date
2022-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
52
Peptide accession
O95602
Residue number A
104
Residue number B
112
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 104 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 112 of DNA-directed RNA polymerase I subunit RPA1
7oba A 764 A 765
A redox-regulated disulphide may form within DNA-directed RNA polymerase I subunit RPA1 between cysteines 764 and 765. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
O95602
Residue number A
764
Residue number B
765
Peptide name
DNA-directed RNA polymerase I subunit RPA1
Ligandability
Cysteine 764 of DNA-directed RNA polymerase I subunit RPA1
Cysteine 765 of DNA-directed RNA polymerase I subunit RPA1
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