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Cleavage and polyadenylation specificity factor subunit 4

Intramolecular
Cysteine 76 and cysteine 82
Cysteine 41 and cysteine 49 L
Cysteine 148 and cysteine 162
Cysteine 124 and cysteine 138 L
Cysteine 132 and cysteine 138
Cysteine 68 and cysteine 82
Cysteine 41 and cysteine 55 L
Cysteine 148 and cysteine 156 L
Cysteine 68 and cysteine 76
Cysteine 156 and cysteine 162 L
More...
Cysteine 124 and cysteine 132 L
Cysteine 96 and cysteine 110
Cysteine 96 and cysteine 105
Cysteine 49 and cysteine 55
Cysteine 105 and cysteine 110
A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 76 and 82.

Details

Redox score ?
88
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
0
Peptide accession
O95639
Residue number A
76
Residue number B
82
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 76 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 41 and 49.

Details

Redox score ?
87
PDB code
8e3q
Structure name
cryo-em structure of the human mpsf
Structure deposition date
2022-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
12
Peptide accession
O95639
Residue number A
41
Residue number B
49
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 41 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 49 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 148 and 162.

Details

Redox score ?
86
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
14
Peptide accession
O95639-2
Residue number A
148
Residue number B
162
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 148 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 124 and 138.

Details

Redox score ?
85
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
22
Peptide accession
O95639-2
Residue number A
124
Residue number B
138
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 124 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 132 and 138.

Details

Redox score ?
84
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
27
Peptide accession
O95639-2
Residue number A
132
Residue number B
138
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 132 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 68 and 82.

Details

Redox score ?
83
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
12
Peptide accession
O95639
Residue number A
68
Residue number B
82
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 68 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 41 and 55.

Details

Redox score ?
82
PDB code
8e3q
Structure name
cryo-em structure of the human mpsf
Structure deposition date
2022-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
24
Peptide accession
O95639
Residue number A
41
Residue number B
55
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 41 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 148 and 156.

Details

Redox score ?
82
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
23
Peptide accession
O95639-2
Residue number A
148
Residue number B
156
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 148 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 68 and 76.

Details

Redox score ?
81
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
12
Peptide accession
O95639
Residue number A
68
Residue number B
76
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 68 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 156 and 162.

Details

Redox score ?
81
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
16
Peptide accession
O95639-2
Residue number A
156
Residue number B
162
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 156 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4 between cysteines 124 and 132.

Details

Redox score ?
77
PDB code
7k95
Structure name
crystal structure of human cpsf30 in complex with hfip1
Structure deposition date
2020-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
38
Peptide accession
O95639-2
Residue number A
124
Residue number B
132
Peptide name
Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 124 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 96 and 110.

Details

Redox score ?
74
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
70
Peptide accession
O95639
Residue number A
96
Residue number B
110
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 96 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 96 and 105.

Details

Redox score ?
73
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
O95639
Residue number A
96
Residue number B
105
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 96 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 49 and 55.

Details

Redox score ?
65
PDB code
6urg
Structure name
cryo-em structure of human cpsf160-wdr33-cpsf30-cpsf100 pim complex
Structure deposition date
2019-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
13
Peptide accession
O95639
Residue number A
49
Residue number B
55
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 49 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 4 between cysteines 105 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2rhk
Structure name
crystal structure of influenza a ns1a protein in complex with f2f3 fragment of human cellular factor cpsf30, northeast structural genomics targets or8c and hr6309a
Structure deposition date
2007-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
18
% buried
nan
Peptide accession
O95639
Residue number A
105
Residue number B
110
Peptide name
Cleavage and polyadenylation specificity factor subunit 4

Ligandability

Cysteine 105 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Cleavage and polyadenylation specificity factor subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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