a tool for identifying drug-targetable redox-active disulphides

Amyloid-beta A4 precursor protein-binding family B member 3

Intramolecular

Cysteine 357 and cysteine 407

A redox-regulated disulphide may form within Amyloid-beta A4 precursor protein-binding family B member 3 between cysteines 357 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

crystal structure of the c-terminal phophotyrosine interaction domain of human apbb3

Structure deposition date

2006-09-16

Thiol separation (Å)

9

Half-sphere exposure sum ?

nan

Minimum pK_a ?

11

% buried

56

Peptide accession

Residue number A

357

Residue number B

407

Peptide name

Amyloid-beta A4 precursor protein-binding family B member 3

Ligandability

Cysteine 357 of Amyloid-beta A4 precursor protein-binding family B member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Amyloid-beta A4 precursor protein-binding family B member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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