ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor 19

Intramolecular
Cysteine 58 and cysteine 70
Cysteine 102 and cysteine 120
A redox-regulated disulphide may form within Fibroblast growth factor 19 between cysteines 58 and 70.

Details

Redox score ?
83
PDB code
6ktr
Structure name
crystal structure of fibroblast growth factor 19 in complex with fab
Structure deposition date
2019-08-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95750
Residue number A
58
Residue number B
70
Peptide name
Fibroblast growth factor 19

Ligandability

Cysteine 58 of Fibroblast growth factor 19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Fibroblast growth factor 19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor 19 between cysteines 102 and 120.

Details

Redox score ?
77
PDB code
6ktr
Structure name
crystal structure of fibroblast growth factor 19 in complex with fab
Structure deposition date
2019-08-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95750
Residue number A
102
Residue number B
120
Peptide name
Fibroblast growth factor 19

Ligandability

Cysteine 102 of Fibroblast growth factor 19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Fibroblast growth factor 19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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