Antiviral innate immune response receptor RIG-I
Intermolecular
Cysteine 829 and cysteine 829
Cysteine 136 and cysteine 13 of Mitochondrial antiviral-signaling protein
Intramolecular
Cysteine 810 and cysteine 869
Cysteine 810 and cysteine 813
Cysteine 810 and cysteine 864
Cysteine 813 and cysteine 864
Cysteine 813 and cysteine 869
Cysteine 864 and cysteine 869
Cysteine 490 and cysteine 520
Cysteine 428 and cysteine 431
More...Cysteine 520 and cysteine 535
Cysteine 841 and cysteine 864
Cysteine 136 and cysteine 143
Cysteine 83 and cysteine 86
Cysteine 818 and cysteine 841
Cysteine 490 and cysteine 535
Cysteine 535 and cysteine 813
Cysteine 810 and cysteine 818
Cysteine 813 and cysteine 841
Cysteine 143 and cysteine 158
Cysteine 841 and cysteine 869
Cysteine 810 and cysteine 841
Cysteine 136 and cysteine 158
Cysteine 709 and cysteine 738
Cysteine 263 and cysteine 374
Cysteine 264 and cysteine 269
Cysteine 818 and cysteine 864
Cysteine 83 and cysteine 130
Cysteine 130 and cysteine 158
Cysteine 130 and cysteine 136
Cysteine 535 and cysteine 810
Cysteine 535 and cysteine 869
Cysteine 374 and cysteine 431
Cysteine 263 and cysteine 431
2qfb A 829 B 829
A redox-regulated disulphide may form between two units of Antiviral innate immune response receptor RIG-I at cysteines 829 and 829.
Details
Redox score ?
77
PDB code
2qfb
Structure name
crystal structure of the regulatory domain of human rig-i with bound zn
Structure deposition date
2007-06-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
86
Peptide A name
Antiviral innate immune response receptor RIG-I
Peptide B name
Antiviral innate immune response receptor RIG-I
Peptide A accession
O95786
Peptide B accession
O95786
Peptide A residue number
829
Peptide B residue number
829
Ligandability
4p4h B 136 I 13
A redox-regulated disulphide may form between cysteine 136 of Antiviral innate immune response receptor RIG-I and cysteine 13 of Mitochondrial antiviral-signaling protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4p4h
Structure name
caught-in-action signaling complex of rig-i 2card domain and mavs card domain
Structure deposition date
2014-03-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
97
Peptide A name
Antiviral innate immune response receptor RIG-I
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
O95786
Peptide B accession
Q7Z434
Peptide A residue number
136
Peptide B residue number
13
Ligandability
Cysteine 136 of Antiviral innate immune response receptor RIG-I
Cysteine 13 of Mitochondrial antiviral-signaling protein
2qfd C 810 C 869
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 810 and 869.
Details
Redox score ?
87
PDB code
2qfd
Structure name
crystal structure of the regulatory domain of human rig-i with bound hg
Structure deposition date
2007-06-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
22
Peptide accession
O95786
Residue number A
810
Residue number B
869
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 810 of Antiviral innate immune response receptor RIG-I
Cysteine 869 of Antiviral innate immune response receptor RIG-I
2qfb F 810 F 813
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 810 and 813.
Details
Redox score ?
86
PDB code
2qfb
Structure name
crystal structure of the regulatory domain of human rig-i with bound zn
Structure deposition date
2007-06-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
36
Peptide accession
O95786
Residue number A
810
Residue number B
813
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 810 of Antiviral innate immune response receptor RIG-I
Cysteine 813 of Antiviral innate immune response receptor RIG-I
2qfb D 810 D 864
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 810 and 864.
Details
Redox score ?
85
PDB code
2qfb
Structure name
crystal structure of the regulatory domain of human rig-i with bound zn
Structure deposition date
2007-06-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
32
Peptide accession
O95786
Residue number A
810
Residue number B
864
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 810 of Antiviral innate immune response receptor RIG-I
Cysteine 864 of Antiviral innate immune response receptor RIG-I
2qfb I 813 I 864
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 813 and 864.
Details
Redox score ?
78
PDB code
2qfb
Structure name
crystal structure of the regulatory domain of human rig-i with bound zn
Structure deposition date
2007-06-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
21
Peptide accession
O95786
Residue number A
813
Residue number B
864
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 813 of Antiviral innate immune response receptor RIG-I
Cysteine 864 of Antiviral innate immune response receptor RIG-I
5f9h C 813 C 869
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 813 and 869.
Details
Redox score ?
77
PDB code
5f9h
Structure name
crystal structure of rig-i helicase-rd in complex with 24-mer 5' triphosphate hairpin rna
Structure deposition date
2015-12-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
4
% buried
94
Peptide accession
O95786
Residue number A
813
Residue number B
869
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 813 of Antiviral innate immune response receptor RIG-I
Cysteine 869 of Antiviral innate immune response receptor RIG-I
6gpg A 864 A 869
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 864 and 869.
Details
Redox score ?
72
PDB code
6gpg
Structure name
structure of the rig-i singleton-merten syndrome variant c268f
Structure deposition date
2018-06-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
65
Peptide accession
O95786
Residue number A
864
Residue number B
869
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 864 of Antiviral innate immune response receptor RIG-I
Cysteine 869 of Antiviral innate immune response receptor RIG-I
5f9f K 490 K 520
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 490 and 520.
Details
Redox score ?
63
PDB code
5f9f
Structure name
crystal structure of rig-i helicase-rd in complex with 24-mer blunt- end hairpin rna
Structure deposition date
2015-12-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
38
Peptide accession
O95786
Residue number A
490
Residue number B
520
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 490 of Antiviral innate immune response receptor RIG-I
Cysteine 520 of Antiviral innate immune response receptor RIG-I
6gpg A 428 A 431
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 428 and 431. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6gpg
Structure name
structure of the rig-i singleton-merten syndrome variant c268f
Structure deposition date
2018-06-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
84
Peptide accession
O95786
Residue number A
428
Residue number B
431
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 428 of Antiviral innate immune response receptor RIG-I
Cysteine 431 of Antiviral innate immune response receptor RIG-I
5e3h A 520 A 535
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 520 and 535. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
5e3h
Structure name
structural basis for rna recognition and activation of rig-i
Structure deposition date
2015-10-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
32
Peptide accession
O95786
Residue number A
520
Residue number B
535
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 520 of Antiviral innate immune response receptor RIG-I
Cysteine 535 of Antiviral innate immune response receptor RIG-I
7bai A 841 A 864
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 841 and 864. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7bai
Structure name
structure of rig-i ctd (i875a) bound to p-rna
Structure deposition date
2020-12-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
26
Peptide accession
O95786
Residue number A
841
Residue number B
864
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 841 of Antiviral innate immune response receptor RIG-I
Cysteine 864 of Antiviral innate immune response receptor RIG-I
2lwe A 136 A 143
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 136 and 143. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2lwe
Structure name
solution structure of mutant (t170e) second card of human rig-i
Structure deposition date
2012-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
18
Peptide accession
O95786
Residue number A
136
Residue number B
143
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 136 of Antiviral innate immune response receptor RIG-I
Cysteine 143 of Antiviral innate immune response receptor RIG-I
6bzh A 83 A 86
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 83 and 86. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6bzh
Structure name
structure of mouse rig-i tandem cards
Structure deposition date
2017-12-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
38
Peptide accession
Q6Q899
Residue number A
83
Residue number B
86
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 83 of Antiviral innate immune response receptor RIG-I
Cysteine 86 of Antiviral innate immune response receptor RIG-I
6kyv F 818 F 841
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 818 and 841. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6kyv
Structure name
crystal structure of rig-i and hairpin rna with g-u wobble base pairs
Structure deposition date
2019-09-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
68
Peptide accession
O95786
Residue number A
818
Residue number B
841
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 818 of Antiviral innate immune response receptor RIG-I
Cysteine 841 of Antiviral innate immune response receptor RIG-I
6kyv D 490 D 535
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 490 and 535. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6kyv
Structure name
crystal structure of rig-i and hairpin rna with g-u wobble base pairs
Structure deposition date
2019-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
46
Peptide accession
O95786
Residue number A
490
Residue number B
535
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 490 of Antiviral innate immune response receptor RIG-I
Cysteine 535 of Antiviral innate immune response receptor RIG-I
6kyv B 535 B 813
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 535 and 813. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6kyv
Structure name
crystal structure of rig-i and hairpin rna with g-u wobble base pairs
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
6
% buried
75
Peptide accession
O95786
Residue number A
535
Residue number B
813
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 535 of Antiviral innate immune response receptor RIG-I
Cysteine 813 of Antiviral innate immune response receptor RIG-I
2rmj A 810 A 818
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 810 and 818. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2rmj
Structure name
solution structure of rig-i c-terminal domain
Structure deposition date
2007-10-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
74
Peptide accession
O95786
Residue number A
810
Residue number B
818
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 810 of Antiviral innate immune response receptor RIG-I
Cysteine 818 of Antiviral innate immune response receptor RIG-I
6gpg A 813 A 841
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 813 and 841. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6gpg
Structure name
structure of the rig-i singleton-merten syndrome variant c268f
Structure deposition date
2018-06-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
nan
Peptide accession
O95786
Residue number A
813
Residue number B
841
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 813 of Antiviral innate immune response receptor RIG-I
Cysteine 841 of Antiviral innate immune response receptor RIG-I
2lwd A 143 A 158
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 143 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
2lwd
Structure name
solution structure of second card of human rig-i
Structure deposition date
2012-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
48
Peptide accession
O95786
Residue number A
143
Residue number B
158
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 143 of Antiviral innate immune response receptor RIG-I
Cysteine 158 of Antiviral innate immune response receptor RIG-I
5f98 K 841 K 869
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 841 and 869. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5f98
Structure name
crystal structure of rig-i in complex with cap-0 rna
Structure deposition date
2015-12-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
44
Peptide accession
O95786
Residue number A
841
Residue number B
869
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 841 of Antiviral innate immune response receptor RIG-I
Cysteine 869 of Antiviral innate immune response receptor RIG-I
5f98 I 810 I 841
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 810 and 841. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5f98
Structure name
crystal structure of rig-i in complex with cap-0 rna
Structure deposition date
2015-12-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
nan
Peptide accession
O95786
Residue number A
810
Residue number B
841
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 810 of Antiviral innate immune response receptor RIG-I
Cysteine 841 of Antiviral innate immune response receptor RIG-I
4nqk D 136 D 158
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 136 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4nqk
Structure name
structure of an ubiquitin complex
Structure deposition date
2013-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
82
Peptide accession
O95786
Residue number A
136
Residue number B
158
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 136 of Antiviral innate immune response receptor RIG-I
Cysteine 158 of Antiviral innate immune response receptor RIG-I
4on9 A 709 A 738
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 709 and 738. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4on9
Structure name
dech box helicase domain
Structure deposition date
2014-01-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
88
Peptide accession
O95786
Residue number A
709
Residue number B
738
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 709 of Antiviral innate immune response receptor RIG-I
Cysteine 738 of Antiviral innate immune response receptor RIG-I
5f98 C 263 C 374
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 263 and 374. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5f98
Structure name
crystal structure of rig-i in complex with cap-0 rna
Structure deposition date
2015-12-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
O95786
Residue number A
263
Residue number B
374
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 263 of Antiviral innate immune response receptor RIG-I
Cysteine 374 of Antiviral innate immune response receptor RIG-I
3tbk A 264 A 269
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 264 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3tbk
Structure name
mouse rig-i atpase domain
Structure deposition date
2011-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
86
Peptide accession
Q6Q899
Residue number A
264
Residue number B
269
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 264 of Antiviral innate immune response receptor RIG-I
Cysteine 269 of Antiviral innate immune response receptor RIG-I
2rmj A 818 A 864
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 818 and 864. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
2rmj
Structure name
solution structure of rig-i c-terminal domain
Structure deposition date
2007-10-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
58
Peptide accession
O95786
Residue number A
818
Residue number B
864
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 818 of Antiviral innate immune response receptor RIG-I
Cysteine 864 of Antiviral innate immune response receptor RIG-I
6bzh A 83 A 130
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 83 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6bzh
Structure name
structure of mouse rig-i tandem cards
Structure deposition date
2017-12-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
49
Peptide accession
Q6Q899
Residue number A
83
Residue number B
130
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 83 of Antiviral innate immune response receptor RIG-I
Cysteine 130 of Antiviral innate immune response receptor RIG-I
2lwe A 130 A 158
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 130 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
2lwe
Structure name
solution structure of mutant (t170e) second card of human rig-i
Structure deposition date
2012-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
12
% buried
50
Peptide accession
O95786
Residue number A
130
Residue number B
158
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 130 of Antiviral innate immune response receptor RIG-I
Cysteine 158 of Antiviral innate immune response receptor RIG-I
4p4h D 130 D 136
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 130 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
4p4h
Structure name
caught-in-action signaling complex of rig-i 2card domain and mavs card domain
Structure deposition date
2014-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
94
Peptide accession
O95786
Residue number A
130
Residue number B
136
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 130 of Antiviral innate immune response receptor RIG-I
Cysteine 136 of Antiviral innate immune response receptor RIG-I
5f9h A 535 A 810
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 535 and 810. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5f9h
Structure name
crystal structure of rig-i helicase-rd in complex with 24-mer 5' triphosphate hairpin rna
Structure deposition date
2015-12-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
nan
Peptide accession
O95786
Residue number A
535
Residue number B
810
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 535 of Antiviral innate immune response receptor RIG-I
Cysteine 810 of Antiviral innate immune response receptor RIG-I
6gpg A 535 A 869
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 535 and 869. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6gpg
Structure name
structure of the rig-i singleton-merten syndrome variant c268f
Structure deposition date
2018-06-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
74
Peptide accession
O95786
Residue number A
535
Residue number B
869
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 535 of Antiviral innate immune response receptor RIG-I
Cysteine 869 of Antiviral innate immune response receptor RIG-I
5f9h E 374 E 431
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 374 and 431. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5f9h
Structure name
crystal structure of rig-i helicase-rd in complex with 24-mer 5' triphosphate hairpin rna
Structure deposition date
2015-12-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
O95786
Residue number A
374
Residue number B
431
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 374 of Antiviral innate immune response receptor RIG-I
Cysteine 431 of Antiviral innate immune response receptor RIG-I
5f9h E 263 E 431
A redox-regulated disulphide may form within Antiviral innate immune response receptor RIG-I between cysteines 263 and 431. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
5f9h
Structure name
crystal structure of rig-i helicase-rd in complex with 24-mer 5' triphosphate hairpin rna
Structure deposition date
2015-12-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
O95786
Residue number A
263
Residue number B
431
Peptide name
Antiviral innate immune response receptor RIG-I
Ligandability
Cysteine 263 of Antiviral innate immune response receptor RIG-I
Cysteine 431 of Antiviral innate immune response receptor RIG-I
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