Mitogen-activated protein kinase kinase kinase kinase 4

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Mitogen-activated protein kinase kinase kinase kinase 4 at cysteines 202 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4zk5

Structure name

map4k4 in complex with inhibitor gne-495

Structure deposition date

2015-04-29

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Mitogen-activated protein kinase kinase kinase kinase 4

Peptide B name

Mitogen-activated protein kinase kinase kinase kinase 4

Peptide A accession

O95819

Peptide B accession

O95819

Peptide A residue number

202

Peptide B residue number

202

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase kinase 4 between cysteines 219 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?