a tool for identifying drug-targetable redox-active disulphides

Chloride intracellular channel protein 3

Intramolecular

Cysteine 22 and cysteine 25 L

A redox-regulated disulphide may form within Chloride intracellular channel protein 3 between cysteines 22 and 25.

Details

Redox score ?

75

PDB code

Structure name

crystal structure of reduced homo sapiens clic3

Structure deposition date

2009-11-04

Thiol separation (Å)

3

Half-sphere exposure sum ?

80

Minimum pK_a ?

6

% buried

84

Peptide accession

Residue number A

22

Residue number B

25

Peptide name

Chloride intracellular channel protein 3

Ligandability

Cysteine 22 of Chloride intracellular channel protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Chloride intracellular channel protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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