ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Uridine diphosphate glucose pyrophosphatase NUDT14

Intramolecular
Cysteine 104 and cysteine 127
Cysteine 104 and cysteine 120
A redox-regulated disulphide may form within Uridine diphosphate glucose pyrophosphatase NUDT14 between cysteines 104 and 127.

Details

Redox score ?
69
PDB code
3q91
Structure name
crystal structure of human uridine diphosphate glucose pyrophosphatase (nudt14)
Structure deposition date
2011-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
95
Peptide accession
O95848
Residue number A
104
Residue number B
127
Peptide name
Uridine diphosphate glucose pyrophosphatase NUDT14

Ligandability

Cysteine 104 of Uridine diphosphate glucose pyrophosphatase NUDT14

Cysteine 127 of Uridine diphosphate glucose pyrophosphatase NUDT14

A redox-regulated disulphide may form within Uridine diphosphate glucose pyrophosphatase NUDT14 between cysteines 104 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3q91
Structure name
crystal structure of human uridine diphosphate glucose pyrophosphatase (nudt14)
Structure deposition date
2011-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
65
Peptide accession
O95848
Residue number A
104
Residue number B
120
Peptide name
Uridine diphosphate glucose pyrophosphatase NUDT14

Ligandability

Cysteine 104 of Uridine diphosphate glucose pyrophosphatase NUDT14

Cysteine 120 of Uridine diphosphate glucose pyrophosphatase NUDT14

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