Zinc finger protein SNAI1
Intermolecular
Cysteine 471 of Importin subunit beta-1 and cysteine 262
Intramolecular
Cysteine 182 and cysteine 185
Cysteine 156 and cysteine 159
Cysteine 210 and cysteine 213
Cysteine 238 and cysteine 259
Cysteine 238 and cysteine 241
Cysteine 241 and cysteine 259
Cysteine 241 and cysteine 262
Cysteine 259 and cysteine 262
3w5k A 471 B 262
A redox-regulated disulphide may form between cysteine 471 of Importin subunit beta-1 and cysteine 262 of Zinc finger protein SNAI1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide A name
Importin subunit beta-1
Peptide B name
Zinc finger protein SNAI1
Peptide A accession
Q14974
Peptide B accession
O95863
Peptide A residue number
471
Peptide B residue number
262
Ligandability
Cysteine 471 of Importin subunit beta-1
Cysteine 262 of Zinc finger protein SNAI1
3w5k B 182 B 185
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 182 and 185.
Details
Redox score ?
86
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
15
Peptide accession
O95863
Residue number A
182
Residue number B
185
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 182 of Zinc finger protein SNAI1
Cysteine 185 of Zinc finger protein SNAI1
3w5k B 156 B 159
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 156 and 159.
Details
Redox score ?
82
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
2
Peptide accession
O95863
Residue number A
156
Residue number B
159
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 156 of Zinc finger protein SNAI1
Cysteine 159 of Zinc finger protein SNAI1
3w5k B 210 B 213
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 210 and 213.
Details
Redox score ?
76
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
48
Peptide accession
O95863
Residue number A
210
Residue number B
213
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 210 of Zinc finger protein SNAI1
Cysteine 213 of Zinc finger protein SNAI1
3w5k B 238 B 259
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 238 and 259.
Details
Redox score ?
73
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
90
Peptide accession
O95863
Residue number A
238
Residue number B
259
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 238 of Zinc finger protein SNAI1
Cysteine 259 of Zinc finger protein SNAI1
3w5k B 238 B 241
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 238 and 241.
Details
Redox score ?
71
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
nan
Peptide accession
O95863
Residue number A
238
Residue number B
241
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 238 of Zinc finger protein SNAI1
Cysteine 241 of Zinc finger protein SNAI1
3w5k B 241 B 259
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 241 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
20
% buried
nan
Peptide accession
O95863
Residue number A
241
Residue number B
259
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 241 of Zinc finger protein SNAI1
Cysteine 259 of Zinc finger protein SNAI1
3w5k B 241 B 262
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 241 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
nan
Peptide accession
O95863
Residue number A
241
Residue number B
262
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 241 of Zinc finger protein SNAI1
Cysteine 262 of Zinc finger protein SNAI1
3w5k B 259 B 262
A redox-regulated disulphide may form within Zinc finger protein SNAI1 between cysteines 259 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
3w5k
Structure name
crystal structure of snail1 and importin beta complex
Structure deposition date
2013-01-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
100
Peptide accession
O95863
Residue number A
259
Residue number B
262
Peptide name
Zinc finger protein SNAI1
Ligandability
Cysteine 259 of Zinc finger protein SNAI1
Cysteine 262 of Zinc finger protein SNAI1
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